AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies

Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targeting insoluble, aggregated α-synuclein are already being activ...

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Detalles Bibliográficos
Autores principales: Düchs, Matthias, Blazevic, Dragica, Rechtsteiner, Philipp, Kenny, Cynthia, Lamla, Thorsten, Low, Sarah, Savistchenko, Jimmy, Neumann, Manuela, Melki, Ronald, Schönberger, Tanja, Stierstorfer, Birgit, Wyatt, David, Igney, Frederik, Ciossek, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272115/
https://www.ncbi.nlm.nih.gov/pubmed/37322068
http://dx.doi.org/10.1038/s41531-023-00542-9

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