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Urinary titin N-fragment as a predictor of decreased skeletal muscle mass in patients with interstitial lung diseases

This study aimed to examine the validity of urinary N-terminal titin fragment/creatinine (urinary N-titin/Cr) reflecting muscle damage biomarker in patients with interstitial lung disease. This retrospective study enrolled patients with interstitial lung disease. We measured urinary N-titin/Cr. Furt...

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Detalles Bibliográficos
Autores principales: Hanada, Masatoshi, Ishimatsu, Yuji, Sakamoto, Noriho, Akiyama, Yoshiko, Kido, Takashi, Ishimoto, Hiroshi, Oikawa, Masato, Nagura, Hiroki, Takeuchi, Rina, Sato, Shuntaro, Takahata, Hideaki, Mukae, Hiroshi, Kozu, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272142/
https://www.ncbi.nlm.nih.gov/pubmed/37322176
http://dx.doi.org/10.1038/s41598-023-36827-5
Descripción
Sumario:This study aimed to examine the validity of urinary N-terminal titin fragment/creatinine (urinary N-titin/Cr) reflecting muscle damage biomarker in patients with interstitial lung disease. This retrospective study enrolled patients with interstitial lung disease. We measured urinary N-titin/Cr. Furthermore, we measured the cross-sectional areas of the pectoralis muscles above the aortic arch (PM(CSA)) and erector spinae muscles of the 12th thoracic vertebra muscles (ESM(CSA)) to assess muscle mass until 1 year. We examined the correlation between urinary N-titin/Cr and the change in muscle mass. We plotted receiver operating characteristic curves to estimate the cut-off points for urinary N-titin/Cr for distinguishing the greater-than-median and smaller-than-median reduction of muscle mass after 1 year. We enrolled 68 patients with interstitial lung disease. The median urinary N-titin/Cr value was 7.0 pmol/mg/dL. We observed significant negative correlations between urinary N-titin/Cr and changes in the PM(CSA) after 1 year (p < 0.001) and changes in the ESM(CSA) after 6 months (p < 0.001) and 1 year (p < 0.001). The cut-off points for urinary N-titin/Cr were 5.2 pmol/mg/dL and 10.4 pmol/mg/dL in the PM(CSA) and ESM(CSA), respectively. In summary, urinary N-titin/Cr may predict muscle loss in the long-term and act as a clinically useful biomarker reflecting muscle damage.