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PPP2R1A regulates migration persistence through the NHSL1-containing WAVE Shell Complex

The RAC1-WAVE-Arp2/3 signaling pathway generates branched actin networks that power lamellipodium protrusion of migrating cells. Feedback is thought to control protrusion lifetime and migration persistence, but its molecular circuitry remains elusive. Here, we identify PPP2R1A by proteomics as a pro...

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Detalles Bibliográficos
Autores principales:	Wang, Yanan, Chiappetta, Giovanni, Guérois, Raphaël, Liu, Yijun, Romero, Stéphane, Boesch, Daniel J., Krause, Matthias, Dessalles, Claire A., Babataheri, Avin, Barakat, Abdul I., Chen, Baoyu, Vinh, Joelle, Polesskaya, Anna, Gautreau, Alexis M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272187/ https://www.ncbi.nlm.nih.gov/pubmed/37322026 http://dx.doi.org/10.1038/s41467-023-39276-w

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