Cargando…

Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease

Age-related cognitive impairment have increased dramatically in recent years, which has risen the interes in developing screening tools for mild cognitive impairment and Alzheimer's disease. Speech analysis allows to exploit the behavioral consequences of cognitive deficits on the patient'...

Descripción completa

Detalles Bibliográficos
Autores principales: Martínez-Nicolás, Israel, Martínez-Sánchez, Francisco, Ivanova, Olga, Meilán, Juan J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272227/
https://www.ncbi.nlm.nih.gov/pubmed/37322073
http://dx.doi.org/10.1038/s41598-023-36804-y
_version_ 1785059447963385856
author Martínez-Nicolás, Israel
Martínez-Sánchez, Francisco
Ivanova, Olga
Meilán, Juan J. G.
author_facet Martínez-Nicolás, Israel
Martínez-Sánchez, Francisco
Ivanova, Olga
Meilán, Juan J. G.
author_sort Martínez-Nicolás, Israel
collection PubMed
description Age-related cognitive impairment have increased dramatically in recent years, which has risen the interes in developing screening tools for mild cognitive impairment and Alzheimer's disease. Speech analysis allows to exploit the behavioral consequences of cognitive deficits on the patient's vocal performance so that it is possible to identify pathologies affecting speech production such as dementia. Previous studies have further shown that the speech task used determines how the speech parameters are altered. We aim to combine the impairments in several speech production tasks in order to improve the accuracy of screening through speech analysis. The sample consists of 72 participants divided into three equal groups of healthy older adults, people with mild cognitive impairment, or Alzheimer's disease, matched by age and education. A complete neuropsychological assessment and two voice recordings were performed. The tasks required the participants to read a text, and complete a sentence with semantic information. A stepwise linear discriminant analysis was performed to select speech parameters with discriminative power. The discriminative functions obtained an accuracy of 83.3% in simultaneous classifications of several levels of cognitive impairment. It would therefore be a promising screening tool for dementia.
format Online
Article
Text
id pubmed-10272227
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-102722272023-06-17 Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease Martínez-Nicolás, Israel Martínez-Sánchez, Francisco Ivanova, Olga Meilán, Juan J. G. Sci Rep Article Age-related cognitive impairment have increased dramatically in recent years, which has risen the interes in developing screening tools for mild cognitive impairment and Alzheimer's disease. Speech analysis allows to exploit the behavioral consequences of cognitive deficits on the patient's vocal performance so that it is possible to identify pathologies affecting speech production such as dementia. Previous studies have further shown that the speech task used determines how the speech parameters are altered. We aim to combine the impairments in several speech production tasks in order to improve the accuracy of screening through speech analysis. The sample consists of 72 participants divided into three equal groups of healthy older adults, people with mild cognitive impairment, or Alzheimer's disease, matched by age and education. A complete neuropsychological assessment and two voice recordings were performed. The tasks required the participants to read a text, and complete a sentence with semantic information. A stepwise linear discriminant analysis was performed to select speech parameters with discriminative power. The discriminative functions obtained an accuracy of 83.3% in simultaneous classifications of several levels of cognitive impairment. It would therefore be a promising screening tool for dementia. Nature Publishing Group UK 2023-06-15 /pmc/articles/PMC10272227/ /pubmed/37322073 http://dx.doi.org/10.1038/s41598-023-36804-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Martínez-Nicolás, Israel
Martínez-Sánchez, Francisco
Ivanova, Olga
Meilán, Juan J. G.
Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease
title Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease
title_full Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease
title_fullStr Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease
title_full_unstemmed Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease
title_short Reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease
title_sort reading and lexical–semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and alzheimer's disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272227/
https://www.ncbi.nlm.nih.gov/pubmed/37322073
http://dx.doi.org/10.1038/s41598-023-36804-y
work_keys_str_mv AT martineznicolasisrael readingandlexicalsemanticretrievaltasksoutperformssingletaskspeechanalysisinthescreeningofmildcognitiveimpairmentandalzheimersdisease
AT martinezsanchezfrancisco readingandlexicalsemanticretrievaltasksoutperformssingletaskspeechanalysisinthescreeningofmildcognitiveimpairmentandalzheimersdisease
AT ivanovaolga readingandlexicalsemanticretrievaltasksoutperformssingletaskspeechanalysisinthescreeningofmildcognitiveimpairmentandalzheimersdisease
AT meilanjuanjg readingandlexicalsemanticretrievaltasksoutperformssingletaskspeechanalysisinthescreeningofmildcognitiveimpairmentandalzheimersdisease