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Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population

Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are prodrugs of the nucleotide analogue tenofovir, which acts intracellularly to inhibit HIV replication. Whereas TDF converts to tenofovir in plasma and may cause kidney and bone toxicity, TAF mostly converts to tenofovir intracell...

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Detalles Bibliográficos
Autores principales:	Kawuma, Aida N., Wasmann, Roeland E., Sinxadi, Phumla, Sokhela, Simiso M., Chandiwana, Nomathemba, Venter, Willem D. F., Wiesner, Lubbe, Maartens, Gary, Denti, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272303/ https://www.ncbi.nlm.nih.gov/pubmed/37013631 http://dx.doi.org/10.1002/psp4.12955

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