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Physiologically based pharmacokinetic modeling for development and applications of a virtual celiac disease population using felodipine as a model drug

In celiac disease (CeD), gastrointestinal CYP3A4 abundance and morphology is affected by the severity of disease. Therefore, exposure to CYP3A4 substrates and extent of drug interactions is altered. A physiologically‐based pharmacokinetic (PBPK) population for different severities of CeD was develop...

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Detalles Bibliográficos
Autores principales:	Salem, Farzaneh, Nimavardi, Ali, Mudunuru, Jennypher, Tompson, Debra, Bloomer, Jackie, Turner, David B., Taskar, Kunal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272307/ https://www.ncbi.nlm.nih.gov/pubmed/36855819 http://dx.doi.org/10.1002/psp4.12954

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