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The role of gut microbiota in depression: an analysis of the gut-brain axis

The gut-brain axis is a communication pathway that allows a two-way exchange of information between the microbiota of the gastrointestinal tract and the nervous system of humans. The vagus nerve, which is responsible for facilitating communication, provides support for this axis. The gut-brain axis...

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Autores principales: Irum, Natasha, Afzal, Tayyeba, Faraz, Muhammad Hamid, Aslam, Zeeshan, Rasheed, Faisal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272349/
https://www.ncbi.nlm.nih.gov/pubmed/37333479
http://dx.doi.org/10.3389/fnbeh.2023.1185522
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author Irum, Natasha
Afzal, Tayyeba
Faraz, Muhammad Hamid
Aslam, Zeeshan
Rasheed, Faisal
author_facet Irum, Natasha
Afzal, Tayyeba
Faraz, Muhammad Hamid
Aslam, Zeeshan
Rasheed, Faisal
author_sort Irum, Natasha
collection PubMed
description The gut-brain axis is a communication pathway that allows a two-way exchange of information between the microbiota of the gastrointestinal tract and the nervous system of humans. The vagus nerve, which is responsible for facilitating communication, provides support for this axis. The gut-brain axis is currently the subject of research, but studies into the diversity and stratification of the gut microbiota are just getting started. Researchers have discovered several positive trends by analyzing numerous studies examining the gut microbiota’s impact on the effectiveness of SSRIs. It is common knowledge that a specific group of measurable, microbial markers has been recognized as being present in the feces of individuals suffering from depression. Specific bacterial species are a common denominator among therapeutic bacteria used to treat depression. It can also play a role in determining the severity of disease progression. Evidence that selective serotonin reuptake inhibitors (SSRIs) rely on the vagus nerve to exert their therapeutic effects has provided further support for the importance of the vagus nerve in the gut-brain axis, which is necessary for beneficial changes in the gut microbiota. This review will analyze the research linking gut microbiota to depression.
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spelling pubmed-102723492023-06-17 The role of gut microbiota in depression: an analysis of the gut-brain axis Irum, Natasha Afzal, Tayyeba Faraz, Muhammad Hamid Aslam, Zeeshan Rasheed, Faisal Front Behav Neurosci Neuroscience The gut-brain axis is a communication pathway that allows a two-way exchange of information between the microbiota of the gastrointestinal tract and the nervous system of humans. The vagus nerve, which is responsible for facilitating communication, provides support for this axis. The gut-brain axis is currently the subject of research, but studies into the diversity and stratification of the gut microbiota are just getting started. Researchers have discovered several positive trends by analyzing numerous studies examining the gut microbiota’s impact on the effectiveness of SSRIs. It is common knowledge that a specific group of measurable, microbial markers has been recognized as being present in the feces of individuals suffering from depression. Specific bacterial species are a common denominator among therapeutic bacteria used to treat depression. It can also play a role in determining the severity of disease progression. Evidence that selective serotonin reuptake inhibitors (SSRIs) rely on the vagus nerve to exert their therapeutic effects has provided further support for the importance of the vagus nerve in the gut-brain axis, which is necessary for beneficial changes in the gut microbiota. This review will analyze the research linking gut microbiota to depression. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272349/ /pubmed/37333479 http://dx.doi.org/10.3389/fnbeh.2023.1185522 Text en Copyright © 2023 Irum, Afzal, Faraz, Aslam and Rasheed. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Irum, Natasha
Afzal, Tayyeba
Faraz, Muhammad Hamid
Aslam, Zeeshan
Rasheed, Faisal
The role of gut microbiota in depression: an analysis of the gut-brain axis
title The role of gut microbiota in depression: an analysis of the gut-brain axis
title_full The role of gut microbiota in depression: an analysis of the gut-brain axis
title_fullStr The role of gut microbiota in depression: an analysis of the gut-brain axis
title_full_unstemmed The role of gut microbiota in depression: an analysis of the gut-brain axis
title_short The role of gut microbiota in depression: an analysis of the gut-brain axis
title_sort role of gut microbiota in depression: an analysis of the gut-brain axis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272349/
https://www.ncbi.nlm.nih.gov/pubmed/37333479
http://dx.doi.org/10.3389/fnbeh.2023.1185522
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