Coronary microvascular dysfunction in heart failure patients

Coronary microcirculation has multiple layers of autoregulatory function to maintain resting flow and augment hyperemic flow in response to myocardial demands. Functional or structural alterations in the coronary microvascular function are frequently observed in patients with heart failure with pres...

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Autores principales: Toya, Takumi, Nagatomo, Yuji, Ikegami, Yukinori, Masaki, Nobuyuki, Adachi, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272355/
https://www.ncbi.nlm.nih.gov/pubmed/37332583
http://dx.doi.org/10.3389/fcvm.2023.1153994
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author Toya, Takumi
Nagatomo, Yuji
Ikegami, Yukinori
Masaki, Nobuyuki
Adachi, Takeshi
author_facet Toya, Takumi
Nagatomo, Yuji
Ikegami, Yukinori
Masaki, Nobuyuki
Adachi, Takeshi
author_sort Toya, Takumi
collection PubMed
description Coronary microcirculation has multiple layers of autoregulatory function to maintain resting flow and augment hyperemic flow in response to myocardial demands. Functional or structural alterations in the coronary microvascular function are frequently observed in patients with heart failure with preserved or reduced ejection fraction, which may lead to myocardial ischemic injury and resultant worsening of clinical outcomes. In this review, we describe our current understanding of coronary microvascular dysfunction in the pathogenesis of heart failure with preserved and reduced ejection fraction.
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spelling pubmed-102723552023-06-17 Coronary microvascular dysfunction in heart failure patients Toya, Takumi Nagatomo, Yuji Ikegami, Yukinori Masaki, Nobuyuki Adachi, Takeshi Front Cardiovasc Med Cardiovascular Medicine Coronary microcirculation has multiple layers of autoregulatory function to maintain resting flow and augment hyperemic flow in response to myocardial demands. Functional or structural alterations in the coronary microvascular function are frequently observed in patients with heart failure with preserved or reduced ejection fraction, which may lead to myocardial ischemic injury and resultant worsening of clinical outcomes. In this review, we describe our current understanding of coronary microvascular dysfunction in the pathogenesis of heart failure with preserved and reduced ejection fraction. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272355/ /pubmed/37332583 http://dx.doi.org/10.3389/fcvm.2023.1153994 Text en © 2023 Toya, Nagatomo, Ikegami, Masaki and Adachi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Toya, Takumi
Nagatomo, Yuji
Ikegami, Yukinori
Masaki, Nobuyuki
Adachi, Takeshi
Coronary microvascular dysfunction in heart failure patients
title Coronary microvascular dysfunction in heart failure patients
title_full Coronary microvascular dysfunction in heart failure patients
title_fullStr Coronary microvascular dysfunction in heart failure patients
title_full_unstemmed Coronary microvascular dysfunction in heart failure patients
title_short Coronary microvascular dysfunction in heart failure patients
title_sort coronary microvascular dysfunction in heart failure patients
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272355/
https://www.ncbi.nlm.nih.gov/pubmed/37332583
http://dx.doi.org/10.3389/fcvm.2023.1153994
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AT masakinobuyuki coronarymicrovasculardysfunctioninheartfailurepatients
AT adachitakeshi coronarymicrovasculardysfunctioninheartfailurepatients

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