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All tangled up: interactions of the fibrinolytic and innate immune systems

The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens. The awareness of these interlinked process has resulted in the coining of the terms...

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Autor principal: Whyte, Claire S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272372/
https://www.ncbi.nlm.nih.gov/pubmed/37332750
http://dx.doi.org/10.3389/fmed.2023.1212201
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author Whyte, Claire S.
author_facet Whyte, Claire S.
author_sort Whyte, Claire S.
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description The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens. The awareness of these interlinked process has resulted in the coining of the terms “thromboinflammation” and “immunothrombosis.” Once a thrombus is formed it is up to the fibrinolytic system to resolve these clots and remove them from the vasculature. Immune cells contain an arsenal of fibrinolytic regulators and plasmin, the central fibrinolytic enzyme. The fibrinolytic proteins in turn have diverse roles in immunoregulation. Here, the intricate relationship between the fibrinolytic and innate immune system will be discussed.
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spelling pubmed-102723722023-06-17 All tangled up: interactions of the fibrinolytic and innate immune systems Whyte, Claire S. Front Med (Lausanne) Medicine The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens. The awareness of these interlinked process has resulted in the coining of the terms “thromboinflammation” and “immunothrombosis.” Once a thrombus is formed it is up to the fibrinolytic system to resolve these clots and remove them from the vasculature. Immune cells contain an arsenal of fibrinolytic regulators and plasmin, the central fibrinolytic enzyme. The fibrinolytic proteins in turn have diverse roles in immunoregulation. Here, the intricate relationship between the fibrinolytic and innate immune system will be discussed. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272372/ /pubmed/37332750 http://dx.doi.org/10.3389/fmed.2023.1212201 Text en Copyright © 2023 Whyte. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Whyte, Claire S.
All tangled up: interactions of the fibrinolytic and innate immune systems
title All tangled up: interactions of the fibrinolytic and innate immune systems
title_full All tangled up: interactions of the fibrinolytic and innate immune systems
title_fullStr All tangled up: interactions of the fibrinolytic and innate immune systems
title_full_unstemmed All tangled up: interactions of the fibrinolytic and innate immune systems
title_short All tangled up: interactions of the fibrinolytic and innate immune systems
title_sort all tangled up: interactions of the fibrinolytic and innate immune systems
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272372/
https://www.ncbi.nlm.nih.gov/pubmed/37332750
http://dx.doi.org/10.3389/fmed.2023.1212201
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