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All tangled up: interactions of the fibrinolytic and innate immune systems
The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens. The awareness of these interlinked process has resulted in the coining of the terms...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272372/ https://www.ncbi.nlm.nih.gov/pubmed/37332750 http://dx.doi.org/10.3389/fmed.2023.1212201 |
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author | Whyte, Claire S. |
author_facet | Whyte, Claire S. |
author_sort | Whyte, Claire S. |
collection | PubMed |
description | The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens. The awareness of these interlinked process has resulted in the coining of the terms “thromboinflammation” and “immunothrombosis.” Once a thrombus is formed it is up to the fibrinolytic system to resolve these clots and remove them from the vasculature. Immune cells contain an arsenal of fibrinolytic regulators and plasmin, the central fibrinolytic enzyme. The fibrinolytic proteins in turn have diverse roles in immunoregulation. Here, the intricate relationship between the fibrinolytic and innate immune system will be discussed. |
format | Online Article Text |
id | pubmed-10272372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102723722023-06-17 All tangled up: interactions of the fibrinolytic and innate immune systems Whyte, Claire S. Front Med (Lausanne) Medicine The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens. The awareness of these interlinked process has resulted in the coining of the terms “thromboinflammation” and “immunothrombosis.” Once a thrombus is formed it is up to the fibrinolytic system to resolve these clots and remove them from the vasculature. Immune cells contain an arsenal of fibrinolytic regulators and plasmin, the central fibrinolytic enzyme. The fibrinolytic proteins in turn have diverse roles in immunoregulation. Here, the intricate relationship between the fibrinolytic and innate immune system will be discussed. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272372/ /pubmed/37332750 http://dx.doi.org/10.3389/fmed.2023.1212201 Text en Copyright © 2023 Whyte. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Whyte, Claire S. All tangled up: interactions of the fibrinolytic and innate immune systems |
title | All tangled up: interactions of the fibrinolytic and innate immune systems |
title_full | All tangled up: interactions of the fibrinolytic and innate immune systems |
title_fullStr | All tangled up: interactions of the fibrinolytic and innate immune systems |
title_full_unstemmed | All tangled up: interactions of the fibrinolytic and innate immune systems |
title_short | All tangled up: interactions of the fibrinolytic and innate immune systems |
title_sort | all tangled up: interactions of the fibrinolytic and innate immune systems |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272372/ https://www.ncbi.nlm.nih.gov/pubmed/37332750 http://dx.doi.org/10.3389/fmed.2023.1212201 |
work_keys_str_mv | AT whyteclaires alltangledupinteractionsofthefibrinolyticandinnateimmunesystems |