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The role of pyroptosis in cognitive impairment
Cognitive impairment is a major global disease, manifests as a decline in cognitive functioning and endangers the health of the population worldwide. The incidence of cognitive impairment has increased rapidly with an increasingly aging population. Although the mechanisms of cognitive impairment hav...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272378/ https://www.ncbi.nlm.nih.gov/pubmed/37332874 http://dx.doi.org/10.3389/fnins.2023.1206948 |
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author | Yang, Xin Tang, Zhe |
author_facet | Yang, Xin Tang, Zhe |
author_sort | Yang, Xin |
collection | PubMed |
description | Cognitive impairment is a major global disease, manifests as a decline in cognitive functioning and endangers the health of the population worldwide. The incidence of cognitive impairment has increased rapidly with an increasingly aging population. Although the mechanisms of cognitive impairment have partly been elucidated with the development of molecular biological technology, treatment methods are very limited. As a unique form of programmed cell death, pyroptosis is highly pro-inflammatory and is closely associated with the incidence and progression of cognitive impairment. In this review, we discuss the molecular mechanisms of pyroptosis briefly and the research progress on the relationship between pyroptosis and cognitive impairment and its potential therapeutic values, to provide a reference for research in the field of cognitive impairment. |
format | Online Article Text |
id | pubmed-10272378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102723782023-06-17 The role of pyroptosis in cognitive impairment Yang, Xin Tang, Zhe Front Neurosci Neuroscience Cognitive impairment is a major global disease, manifests as a decline in cognitive functioning and endangers the health of the population worldwide. The incidence of cognitive impairment has increased rapidly with an increasingly aging population. Although the mechanisms of cognitive impairment have partly been elucidated with the development of molecular biological technology, treatment methods are very limited. As a unique form of programmed cell death, pyroptosis is highly pro-inflammatory and is closely associated with the incidence and progression of cognitive impairment. In this review, we discuss the molecular mechanisms of pyroptosis briefly and the research progress on the relationship between pyroptosis and cognitive impairment and its potential therapeutic values, to provide a reference for research in the field of cognitive impairment. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272378/ /pubmed/37332874 http://dx.doi.org/10.3389/fnins.2023.1206948 Text en Copyright © 2023 Yang and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Yang, Xin Tang, Zhe The role of pyroptosis in cognitive impairment |
title | The role of pyroptosis in cognitive impairment |
title_full | The role of pyroptosis in cognitive impairment |
title_fullStr | The role of pyroptosis in cognitive impairment |
title_full_unstemmed | The role of pyroptosis in cognitive impairment |
title_short | The role of pyroptosis in cognitive impairment |
title_sort | role of pyroptosis in cognitive impairment |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272378/ https://www.ncbi.nlm.nih.gov/pubmed/37332874 http://dx.doi.org/10.3389/fnins.2023.1206948 |
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