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Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT

With the application of low-dose computed tomography in lung cancer screening, pulmonary nodules have become increasingly detected. Accurate discrimination between primary lung cancer and benign nodules poses a significant clinical challenge. This study aimed to investigate the viability of exhaled...

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Autores principales: Ding, Xiangxiang, Lin, Guihu, Wang, Peiyu, Chen, Haibin, Li, Nan, Yang, Zhi, Qiu, Mantang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272389/
https://www.ncbi.nlm.nih.gov/pubmed/37333820
http://dx.doi.org/10.3389/fonc.2023.1204435
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author Ding, Xiangxiang
Lin, Guihu
Wang, Peiyu
Chen, Haibin
Li, Nan
Yang, Zhi
Qiu, Mantang
author_facet Ding, Xiangxiang
Lin, Guihu
Wang, Peiyu
Chen, Haibin
Li, Nan
Yang, Zhi
Qiu, Mantang
author_sort Ding, Xiangxiang
collection PubMed
description With the application of low-dose computed tomography in lung cancer screening, pulmonary nodules have become increasingly detected. Accurate discrimination between primary lung cancer and benign nodules poses a significant clinical challenge. This study aimed to investigate the viability of exhaled breath as a diagnostic tool for pulmonary nodules and compare the breath test with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)–computed tomography (CT). Exhaled breath was collected by Tedlar bags and analyzed by high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS). A retrospective cohort (n = 100) and a prospective cohort (n = 63) of patients with pulmonary nodules were established. In the validation cohort, the breath test achieved an area under the receiver operating characteristic curve (AUC) of 0.872 (95% CI 0.760–0.983) and a combination of 16 volatile organic compounds achieved an AUC of 0.744 (95% CI 0.7586–0.901). For PET-CT, the SUVmax alone had an AUC of 0.608 (95% CI 0.433–0.784) while after combining with CT image features, 18F-FDG PET-CT had an AUC of 0.821 (95% CI 0.662–0.979). Overall, the study demonstrated the efficacy of a breath test utilizing HPPI-TOFMS for discriminating lung cancer from benign pulmonary nodules. Furthermore, the accuracy achieved by the exhaled breath test was comparable with 18F-FDG PET-CT.
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spelling pubmed-102723892023-06-17 Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT Ding, Xiangxiang Lin, Guihu Wang, Peiyu Chen, Haibin Li, Nan Yang, Zhi Qiu, Mantang Front Oncol Oncology With the application of low-dose computed tomography in lung cancer screening, pulmonary nodules have become increasingly detected. Accurate discrimination between primary lung cancer and benign nodules poses a significant clinical challenge. This study aimed to investigate the viability of exhaled breath as a diagnostic tool for pulmonary nodules and compare the breath test with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)–computed tomography (CT). Exhaled breath was collected by Tedlar bags and analyzed by high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS). A retrospective cohort (n = 100) and a prospective cohort (n = 63) of patients with pulmonary nodules were established. In the validation cohort, the breath test achieved an area under the receiver operating characteristic curve (AUC) of 0.872 (95% CI 0.760–0.983) and a combination of 16 volatile organic compounds achieved an AUC of 0.744 (95% CI 0.7586–0.901). For PET-CT, the SUVmax alone had an AUC of 0.608 (95% CI 0.433–0.784) while after combining with CT image features, 18F-FDG PET-CT had an AUC of 0.821 (95% CI 0.662–0.979). Overall, the study demonstrated the efficacy of a breath test utilizing HPPI-TOFMS for discriminating lung cancer from benign pulmonary nodules. Furthermore, the accuracy achieved by the exhaled breath test was comparable with 18F-FDG PET-CT. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272389/ /pubmed/37333820 http://dx.doi.org/10.3389/fonc.2023.1204435 Text en Copyright © 2023 Ding, Lin, Wang, Chen, Li, Yang and Qiu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ding, Xiangxiang
Lin, Guihu
Wang, Peiyu
Chen, Haibin
Li, Nan
Yang, Zhi
Qiu, Mantang
Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT
title Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT
title_full Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT
title_fullStr Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT
title_full_unstemmed Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT
title_short Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT
title_sort diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18f-fdg pet-ct
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272389/
https://www.ncbi.nlm.nih.gov/pubmed/37333820
http://dx.doi.org/10.3389/fonc.2023.1204435
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