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Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study

INTRODUCTION: Oxidative stress has been implicated in psychiatric disorders, including posttraumatic stress disorder (PTSD). Currently, the status of glutathione (GSH), the brain's most abundant antioxidant, in PTSD remains uncertain. Therefore, the current study investigated brain concentratio...

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Autores principales: Watling, Sarah E., Rhind, Shawn G., Warsh, Jerry, Green, Duncan, McCluskey, Tina, Tong, Junchao, Truong, Peter, Chavez, Sofia, Richardson, J. Don, Kish, Stephen J., Boileau, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272391/
https://www.ncbi.nlm.nih.gov/pubmed/37333909
http://dx.doi.org/10.3389/fpsyt.2023.1195012
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author Watling, Sarah E.
Rhind, Shawn G.
Warsh, Jerry
Green, Duncan
McCluskey, Tina
Tong, Junchao
Truong, Peter
Chavez, Sofia
Richardson, J. Don
Kish, Stephen J.
Boileau, Isabelle
author_facet Watling, Sarah E.
Rhind, Shawn G.
Warsh, Jerry
Green, Duncan
McCluskey, Tina
Tong, Junchao
Truong, Peter
Chavez, Sofia
Richardson, J. Don
Kish, Stephen J.
Boileau, Isabelle
author_sort Watling, Sarah E.
collection PubMed
description INTRODUCTION: Oxidative stress has been implicated in psychiatric disorders, including posttraumatic stress disorder (PTSD). Currently, the status of glutathione (GSH), the brain's most abundant antioxidant, in PTSD remains uncertain. Therefore, the current study investigated brain concentrations of GSH and peripheral concentrations of blood markers in individuals with PTSD vs. Healthy Controls (HC). METHODS: GSH spectra was acquired in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) using MEGA-PRESS, a J-difference-editing acquisition method. Peripheral blood samples were analyzed for concentrations of metalloproteinase (MMP)-9, tissue inhibitors of MMP (TIMP)-1,2, and myeloperoxidase (MPO). RESULTS: There was no difference in GSH between PTSD and HC in the ACC (n = 30 PTSD, n = 20 HC) or DLPFC (n = 14 PTSD, n = 18 HC). There were no group differences between peripheral blood markers (P > 0.3) except for (non-significantly) lower TIMP-2 in PTSD. Additionally, TIMP-2 and GSH in the ACC were positively related in those with PTSD. Finally, MPO and MMP-9 were negatively associated with duration of PTSD. CONCLUSIONS: We do not report altered GSH concentrations in the ACC or DLPFC in PTSD, however, systemic MMPs and MPO might be implicated in central processes and progression of PTSD. Future research should investigate these relationships in larger sample sizes.
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spelling pubmed-102723912023-06-17 Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study Watling, Sarah E. Rhind, Shawn G. Warsh, Jerry Green, Duncan McCluskey, Tina Tong, Junchao Truong, Peter Chavez, Sofia Richardson, J. Don Kish, Stephen J. Boileau, Isabelle Front Psychiatry Psychiatry INTRODUCTION: Oxidative stress has been implicated in psychiatric disorders, including posttraumatic stress disorder (PTSD). Currently, the status of glutathione (GSH), the brain's most abundant antioxidant, in PTSD remains uncertain. Therefore, the current study investigated brain concentrations of GSH and peripheral concentrations of blood markers in individuals with PTSD vs. Healthy Controls (HC). METHODS: GSH spectra was acquired in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) using MEGA-PRESS, a J-difference-editing acquisition method. Peripheral blood samples were analyzed for concentrations of metalloproteinase (MMP)-9, tissue inhibitors of MMP (TIMP)-1,2, and myeloperoxidase (MPO). RESULTS: There was no difference in GSH between PTSD and HC in the ACC (n = 30 PTSD, n = 20 HC) or DLPFC (n = 14 PTSD, n = 18 HC). There were no group differences between peripheral blood markers (P > 0.3) except for (non-significantly) lower TIMP-2 in PTSD. Additionally, TIMP-2 and GSH in the ACC were positively related in those with PTSD. Finally, MPO and MMP-9 were negatively associated with duration of PTSD. CONCLUSIONS: We do not report altered GSH concentrations in the ACC or DLPFC in PTSD, however, systemic MMPs and MPO might be implicated in central processes and progression of PTSD. Future research should investigate these relationships in larger sample sizes. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272391/ /pubmed/37333909 http://dx.doi.org/10.3389/fpsyt.2023.1195012 Text en Copyright © 2023 Watling, Rhind, Warsh, Green, McCluskey, Tong, Truong, Chavez, Richardson, Kish and Boileau. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Watling, Sarah E.
Rhind, Shawn G.
Warsh, Jerry
Green, Duncan
McCluskey, Tina
Tong, Junchao
Truong, Peter
Chavez, Sofia
Richardson, J. Don
Kish, Stephen J.
Boileau, Isabelle
Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study
title Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study
title_full Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study
title_fullStr Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study
title_full_unstemmed Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study
title_short Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study
title_sort exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1h]mrs and peripheral blood study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272391/
https://www.ncbi.nlm.nih.gov/pubmed/37333909
http://dx.doi.org/10.3389/fpsyt.2023.1195012
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