Cargando…

Ceramide in cerebrovascular diseases

Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Huiqi, Zhu, Bin, Li, Cao, Zhao, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272456/
https://www.ncbi.nlm.nih.gov/pubmed/37333888
http://dx.doi.org/10.3389/fncel.2023.1191609
_version_ 1785059498991288320
author Yuan, Huiqi
Zhu, Bin
Li, Cao
Zhao, Zhigang
author_facet Yuan, Huiqi
Zhu, Bin
Li, Cao
Zhao, Zhigang
author_sort Yuan, Huiqi
collection PubMed
description Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated with a variety of brain disorders. Cerebrovascular diseases, which are mainly caused by abnormal cerebral blood flow and secondary neurological injury, are the leading causes of death and disability worldwide. There is a growing body of evidence for a close connection between elevated ceramide levels and cerebrovascular diseases, especially stroke and cerebral small vessel disease (CSVD). The increased ceramide has broad effects on different types of brain cells, including endothelial cells, microglia, and neurons. Therefore, strategies that reduce ceramide synthesis, such as modifying sphingomyelinase activity or the rate-limiting enzyme of the de novo synthesis pathway, serine palmitoyltransferase, may represent novel and promising therapeutic approaches to prevent or treat cerebrovascular injury-related diseases.
format Online
Article
Text
id pubmed-10272456
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102724562023-06-17 Ceramide in cerebrovascular diseases Yuan, Huiqi Zhu, Bin Li, Cao Zhao, Zhigang Front Cell Neurosci Neuroscience Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated with a variety of brain disorders. Cerebrovascular diseases, which are mainly caused by abnormal cerebral blood flow and secondary neurological injury, are the leading causes of death and disability worldwide. There is a growing body of evidence for a close connection between elevated ceramide levels and cerebrovascular diseases, especially stroke and cerebral small vessel disease (CSVD). The increased ceramide has broad effects on different types of brain cells, including endothelial cells, microglia, and neurons. Therefore, strategies that reduce ceramide synthesis, such as modifying sphingomyelinase activity or the rate-limiting enzyme of the de novo synthesis pathway, serine palmitoyltransferase, may represent novel and promising therapeutic approaches to prevent or treat cerebrovascular injury-related diseases. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272456/ /pubmed/37333888 http://dx.doi.org/10.3389/fncel.2023.1191609 Text en Copyright © 2023 Yuan, Zhu, Li and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yuan, Huiqi
Zhu, Bin
Li, Cao
Zhao, Zhigang
Ceramide in cerebrovascular diseases
title Ceramide in cerebrovascular diseases
title_full Ceramide in cerebrovascular diseases
title_fullStr Ceramide in cerebrovascular diseases
title_full_unstemmed Ceramide in cerebrovascular diseases
title_short Ceramide in cerebrovascular diseases
title_sort ceramide in cerebrovascular diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272456/
https://www.ncbi.nlm.nih.gov/pubmed/37333888
http://dx.doi.org/10.3389/fncel.2023.1191609
work_keys_str_mv AT yuanhuiqi ceramideincerebrovasculardiseases
AT zhubin ceramideincerebrovasculardiseases
AT licao ceramideincerebrovasculardiseases
AT zhaozhigang ceramideincerebrovasculardiseases