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Ceramide in cerebrovascular diseases
Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272456/ https://www.ncbi.nlm.nih.gov/pubmed/37333888 http://dx.doi.org/10.3389/fncel.2023.1191609 |
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author | Yuan, Huiqi Zhu, Bin Li, Cao Zhao, Zhigang |
author_facet | Yuan, Huiqi Zhu, Bin Li, Cao Zhao, Zhigang |
author_sort | Yuan, Huiqi |
collection | PubMed |
description | Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated with a variety of brain disorders. Cerebrovascular diseases, which are mainly caused by abnormal cerebral blood flow and secondary neurological injury, are the leading causes of death and disability worldwide. There is a growing body of evidence for a close connection between elevated ceramide levels and cerebrovascular diseases, especially stroke and cerebral small vessel disease (CSVD). The increased ceramide has broad effects on different types of brain cells, including endothelial cells, microglia, and neurons. Therefore, strategies that reduce ceramide synthesis, such as modifying sphingomyelinase activity or the rate-limiting enzyme of the de novo synthesis pathway, serine palmitoyltransferase, may represent novel and promising therapeutic approaches to prevent or treat cerebrovascular injury-related diseases. |
format | Online Article Text |
id | pubmed-10272456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102724562023-06-17 Ceramide in cerebrovascular diseases Yuan, Huiqi Zhu, Bin Li, Cao Zhao, Zhigang Front Cell Neurosci Neuroscience Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated with a variety of brain disorders. Cerebrovascular diseases, which are mainly caused by abnormal cerebral blood flow and secondary neurological injury, are the leading causes of death and disability worldwide. There is a growing body of evidence for a close connection between elevated ceramide levels and cerebrovascular diseases, especially stroke and cerebral small vessel disease (CSVD). The increased ceramide has broad effects on different types of brain cells, including endothelial cells, microglia, and neurons. Therefore, strategies that reduce ceramide synthesis, such as modifying sphingomyelinase activity or the rate-limiting enzyme of the de novo synthesis pathway, serine palmitoyltransferase, may represent novel and promising therapeutic approaches to prevent or treat cerebrovascular injury-related diseases. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272456/ /pubmed/37333888 http://dx.doi.org/10.3389/fncel.2023.1191609 Text en Copyright © 2023 Yuan, Zhu, Li and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Yuan, Huiqi Zhu, Bin Li, Cao Zhao, Zhigang Ceramide in cerebrovascular diseases |
title | Ceramide in cerebrovascular diseases |
title_full | Ceramide in cerebrovascular diseases |
title_fullStr | Ceramide in cerebrovascular diseases |
title_full_unstemmed | Ceramide in cerebrovascular diseases |
title_short | Ceramide in cerebrovascular diseases |
title_sort | ceramide in cerebrovascular diseases |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272456/ https://www.ncbi.nlm.nih.gov/pubmed/37333888 http://dx.doi.org/10.3389/fncel.2023.1191609 |
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