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Deciphering the molecular mechanism of enhanced tumor activity of the EGFR variant T790M/L858R using melanoma cell lines

INTRODUCTION: The abnormal expression and mutagenesis of EGFR drives both the development and progression of a multitude of human cancers. Further mutations within the tyrosine kinase region of the EGFR subsequently contribute to resistance to targeted drugs. What is not known is how these mutations...

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Detalles Bibliográficos
Autores principales:	Shao, Hanshuang, Wells, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272518/ https://www.ncbi.nlm.nih.gov/pubmed/37333807 http://dx.doi.org/10.3389/fonc.2023.1163504

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