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Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels
BACKGROUND: Growing evidence shows the cognitive function influences the motor performance. The prefrontal cortex (PFC) as a part of the executive locomotor pathway is also important for cognitive function. This study investigated the differences in motor function and brain activity among older adul...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272571/ https://www.ncbi.nlm.nih.gov/pubmed/37333460 http://dx.doi.org/10.3389/fnagi.2023.1177082 |
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author | Weng, Wei-Han Yang, Yea-Ru Yeh, Nai-Chen Ku, Pei-Hsin Wang, Po-Shan Liao, Ying-Yi Wang, Ray-Yau |
author_facet | Weng, Wei-Han Yang, Yea-Ru Yeh, Nai-Chen Ku, Pei-Hsin Wang, Po-Shan Liao, Ying-Yi Wang, Ray-Yau |
author_sort | Weng, Wei-Han |
collection | PubMed |
description | BACKGROUND: Growing evidence shows the cognitive function influences the motor performance. The prefrontal cortex (PFC) as a part of the executive locomotor pathway is also important for cognitive function. This study investigated the differences in motor function and brain activity among older adults with different cognitive levels, and examined the significance of cognition on motor functions. METHODS: Normal control (NC), individuals with mild cognitive impairment (MCI) or mild dementia (MD) were enrolled in this study. All participants received a comprehensive assessment including cognitive function, motor function, PFC activity during walking, and fear of fall. The assessment of cognitive function included general cognition, attention, executive function, memory, and visuo-spatial. The assessment of motor function included timed up and go (TUG) test, single walking (SW), and cognitive dual task walking (CDW). RESULTS: Individuals with MD had worse SW, CDW and TUG performance as compared to individuals with MCI and NC. These gait and balance performance did not differ significantly between MCI and NC. Motor functions all correlated with general cognition, attention, executive function, memory, and visuo-spatial ability. Attention ability measured by trail making test A (TMT-A) was the best predictor for TUG and gait velocity. There were no significant differences in PFC activity among three groups. Nevertheless, the PFC activated more during CDW as compared with SW in individuals with MCI (p = 0.000), which was not demonstrated in the other two groups. CONCLUSION: MD demonstrated worse motor function as compared to NC and MCI. The greater PFC activity during CDW in MCI may be considered as a compensatory strategy for maintaining the gait performance. Motor function was related to the cognitive function, and the TMT A was the best predictor for the gait related performance in present study among older adults. |
format | Online Article Text |
id | pubmed-10272571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102725712023-06-17 Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels Weng, Wei-Han Yang, Yea-Ru Yeh, Nai-Chen Ku, Pei-Hsin Wang, Po-Shan Liao, Ying-Yi Wang, Ray-Yau Front Aging Neurosci Aging Neuroscience BACKGROUND: Growing evidence shows the cognitive function influences the motor performance. The prefrontal cortex (PFC) as a part of the executive locomotor pathway is also important for cognitive function. This study investigated the differences in motor function and brain activity among older adults with different cognitive levels, and examined the significance of cognition on motor functions. METHODS: Normal control (NC), individuals with mild cognitive impairment (MCI) or mild dementia (MD) were enrolled in this study. All participants received a comprehensive assessment including cognitive function, motor function, PFC activity during walking, and fear of fall. The assessment of cognitive function included general cognition, attention, executive function, memory, and visuo-spatial. The assessment of motor function included timed up and go (TUG) test, single walking (SW), and cognitive dual task walking (CDW). RESULTS: Individuals with MD had worse SW, CDW and TUG performance as compared to individuals with MCI and NC. These gait and balance performance did not differ significantly between MCI and NC. Motor functions all correlated with general cognition, attention, executive function, memory, and visuo-spatial ability. Attention ability measured by trail making test A (TMT-A) was the best predictor for TUG and gait velocity. There were no significant differences in PFC activity among three groups. Nevertheless, the PFC activated more during CDW as compared with SW in individuals with MCI (p = 0.000), which was not demonstrated in the other two groups. CONCLUSION: MD demonstrated worse motor function as compared to NC and MCI. The greater PFC activity during CDW in MCI may be considered as a compensatory strategy for maintaining the gait performance. Motor function was related to the cognitive function, and the TMT A was the best predictor for the gait related performance in present study among older adults. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272571/ /pubmed/37333460 http://dx.doi.org/10.3389/fnagi.2023.1177082 Text en Copyright © 2023 Weng, Yang, Yeh, Ku, Wang, Liao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Weng, Wei-Han Yang, Yea-Ru Yeh, Nai-Chen Ku, Pei-Hsin Wang, Po-Shan Liao, Ying-Yi Wang, Ray-Yau Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels |
title | Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels |
title_full | Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels |
title_fullStr | Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels |
title_full_unstemmed | Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels |
title_short | Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels |
title_sort | gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272571/ https://www.ncbi.nlm.nih.gov/pubmed/37333460 http://dx.doi.org/10.3389/fnagi.2023.1177082 |
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