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Cathepsins in oral diseases: mechanisms and therapeutic implications
Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. Findings regarding their functions in human physiological processes and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272612/ https://www.ncbi.nlm.nih.gov/pubmed/37334378 http://dx.doi.org/10.3389/fimmu.2023.1203071 |
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author | Jiang, Hao Dong, Zuoxiang Xia, Xiaomin Li, Xue |
author_facet | Jiang, Hao Dong, Zuoxiang Xia, Xiaomin Li, Xue |
author_sort | Jiang, Hao |
collection | PubMed |
description | Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. Findings regarding their functions in human physiological processes and disorders have drawn extensive attention. In this review, we will focus on the relationship between cathepsins and oral diseases. We highlight the structural and functional properties of cathepsins related to oral diseases, as well as the regulatory mechanisms in tissue and cells and their therapeutic uses. Elucidating the associated mechanism between cathepsins and oral diseases is thought to be a promising strategy for the treatment of oral diseases and may be a starting point for further studies at the molecular level. |
format | Online Article Text |
id | pubmed-10272612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102726122023-06-17 Cathepsins in oral diseases: mechanisms and therapeutic implications Jiang, Hao Dong, Zuoxiang Xia, Xiaomin Li, Xue Front Immunol Immunology Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. Findings regarding their functions in human physiological processes and disorders have drawn extensive attention. In this review, we will focus on the relationship between cathepsins and oral diseases. We highlight the structural and functional properties of cathepsins related to oral diseases, as well as the regulatory mechanisms in tissue and cells and their therapeutic uses. Elucidating the associated mechanism between cathepsins and oral diseases is thought to be a promising strategy for the treatment of oral diseases and may be a starting point for further studies at the molecular level. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10272612/ /pubmed/37334378 http://dx.doi.org/10.3389/fimmu.2023.1203071 Text en Copyright © 2023 Jiang, Dong, Xia and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Jiang, Hao Dong, Zuoxiang Xia, Xiaomin Li, Xue Cathepsins in oral diseases: mechanisms and therapeutic implications |
title | Cathepsins in oral diseases: mechanisms and therapeutic implications |
title_full | Cathepsins in oral diseases: mechanisms and therapeutic implications |
title_fullStr | Cathepsins in oral diseases: mechanisms and therapeutic implications |
title_full_unstemmed | Cathepsins in oral diseases: mechanisms and therapeutic implications |
title_short | Cathepsins in oral diseases: mechanisms and therapeutic implications |
title_sort | cathepsins in oral diseases: mechanisms and therapeutic implications |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272612/ https://www.ncbi.nlm.nih.gov/pubmed/37334378 http://dx.doi.org/10.3389/fimmu.2023.1203071 |
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