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Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury
Epithelial regeneration is critical for barrier maintenance and organ function after intestinal radiation injury. Accumulating evidence indicates that the interleukin family members play critical roles in intestinal stem-cell-mediated epithelial regeneration. However, little is known about the relat...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272662/ https://www.ncbi.nlm.nih.gov/pubmed/37291802 http://dx.doi.org/10.1177/09636897231177377 |
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author | Guan, Ruoyu Pan, Mengxue Xu, Xiaoya Du, Lixia Rao, Xinxin Fu, Guoxiang Lv, Tao Zhang, Long Li, Yuanchuang Tang, Peiyuan Zhou, Yi Wang, Yanqing Zhang, Zhen Gao, Jianjun Zhou, Hong Mi, Wenli Hua, Guoqiang |
author_facet | Guan, Ruoyu Pan, Mengxue Xu, Xiaoya Du, Lixia Rao, Xinxin Fu, Guoxiang Lv, Tao Zhang, Long Li, Yuanchuang Tang, Peiyuan Zhou, Yi Wang, Yanqing Zhang, Zhen Gao, Jianjun Zhou, Hong Mi, Wenli Hua, Guoqiang |
author_sort | Guan, Ruoyu |
collection | PubMed |
description | Epithelial regeneration is critical for barrier maintenance and organ function after intestinal radiation injury. Accumulating evidence indicates that the interleukin family members play critical roles in intestinal stem-cell-mediated epithelial regeneration. However, little is known about the relationship between interleukin 33 (IL-33)/ST2 axis and intestinal regeneration after radiation injury. We demonstrate here that IL-33 expression significantly increased after radiation treatment. Deficiency of IL-33/ST2 promotes intestinal epithelial regeneration, resulting in a reduction of mortality during radiation-induced intestine injury. Using ex vivo organoid cultures, we show that recombinant IL-33 promotes intestinal stem cell differentiation. Mechanistically, the effects of IL-33 were mediated by activation of transforming growth factor-β signaling. Our findings reveal a fundamental mechanism by which IL-33 is able to regulate the intestinal crypt regeneration after tissue damage. |
format | Online Article Text |
id | pubmed-10272662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-102726622023-06-17 Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury Guan, Ruoyu Pan, Mengxue Xu, Xiaoya Du, Lixia Rao, Xinxin Fu, Guoxiang Lv, Tao Zhang, Long Li, Yuanchuang Tang, Peiyuan Zhou, Yi Wang, Yanqing Zhang, Zhen Gao, Jianjun Zhou, Hong Mi, Wenli Hua, Guoqiang Cell Transplant Original Article Epithelial regeneration is critical for barrier maintenance and organ function after intestinal radiation injury. Accumulating evidence indicates that the interleukin family members play critical roles in intestinal stem-cell-mediated epithelial regeneration. However, little is known about the relationship between interleukin 33 (IL-33)/ST2 axis and intestinal regeneration after radiation injury. We demonstrate here that IL-33 expression significantly increased after radiation treatment. Deficiency of IL-33/ST2 promotes intestinal epithelial regeneration, resulting in a reduction of mortality during radiation-induced intestine injury. Using ex vivo organoid cultures, we show that recombinant IL-33 promotes intestinal stem cell differentiation. Mechanistically, the effects of IL-33 were mediated by activation of transforming growth factor-β signaling. Our findings reveal a fundamental mechanism by which IL-33 is able to regulate the intestinal crypt regeneration after tissue damage. SAGE Publications 2023-06-08 /pmc/articles/PMC10272662/ /pubmed/37291802 http://dx.doi.org/10.1177/09636897231177377 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Guan, Ruoyu Pan, Mengxue Xu, Xiaoya Du, Lixia Rao, Xinxin Fu, Guoxiang Lv, Tao Zhang, Long Li, Yuanchuang Tang, Peiyuan Zhou, Yi Wang, Yanqing Zhang, Zhen Gao, Jianjun Zhou, Hong Mi, Wenli Hua, Guoqiang Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury |
title | Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury |
title_full | Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury |
title_fullStr | Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury |
title_full_unstemmed | Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury |
title_short | Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury |
title_sort | interleukin-33 potentiates tgf-β signaling to regulate intestinal stem cell regeneration after radiation injury |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272662/ https://www.ncbi.nlm.nih.gov/pubmed/37291802 http://dx.doi.org/10.1177/09636897231177377 |
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