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Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease

BACKGROUND: A hallmark of Parkinson's disease (PD) is progressive loss of dopamine terminals in the basal ganglia, with clinical symptoms including motor and non‐motor manifestations such as bradykinesia, rigidity, and cognitive impairment. Dopamine transporter single‐photon emission computed t...

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Autores principales: Trinh, Ilene, Muralidhar, Angeni, Yang, Justin, Phielipp, Nicolás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272916/
https://www.ncbi.nlm.nih.gov/pubmed/37332639
http://dx.doi.org/10.1002/mdc3.13726
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author Trinh, Ilene
Muralidhar, Angeni
Yang, Justin
Phielipp, Nicolás
author_facet Trinh, Ilene
Muralidhar, Angeni
Yang, Justin
Phielipp, Nicolás
author_sort Trinh, Ilene
collection PubMed
description BACKGROUND: A hallmark of Parkinson's disease (PD) is progressive loss of dopamine terminals in the basal ganglia, with clinical symptoms including motor and non‐motor manifestations such as bradykinesia, rigidity, and cognitive impairment. Dopamine transporter single‐photon emission computed tomography (DaT‐SPECT) can be used to assess dopaminergic denervation by detecting loss of striatal dopamine transporters (DaT). OBJECTIVE: We examined DaT binding scores’ (DaTbs) association with motor outcomes in PD and explored its usefulness as a predictor of disease progression. Faster dopaminergic denervation in the basal ganglia was hypothesized to have stronger correlation and predictive value for poor motor outcomes. METHODS: Data was analyzed from the Parkinson's Progression Markers Initiative. DaTbs in the putamen and caudate nucleus were correlated with Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) scores for walking and balance difficulties, gait difficulties, and presence of dyskinesias. A predictive model using baseline speed of drop in DaT binding score was performed for each motor outcome. RESULTS: All motor outcomes had mild, significantly negative correlation with DaTbs in the putamen and caudate nucleus, with similar degree of correlation per region. Speed of drop was predictive of only substantial gait difficulties when evaluated in the putamen but not the caudate. CONCLUSIONS: These findings suggest that analyzing speed of drop in DaTbs, which occurs early in the motor phase of the disease, may be helpful for predicting clinical outcomes in PD. Longer observation of this cohort may provide further data to investigate DaTbs as a prognostic marker in PD.
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spelling pubmed-102729162023-06-17 Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease Trinh, Ilene Muralidhar, Angeni Yang, Justin Phielipp, Nicolás Mov Disord Clin Pract Research Articles BACKGROUND: A hallmark of Parkinson's disease (PD) is progressive loss of dopamine terminals in the basal ganglia, with clinical symptoms including motor and non‐motor manifestations such as bradykinesia, rigidity, and cognitive impairment. Dopamine transporter single‐photon emission computed tomography (DaT‐SPECT) can be used to assess dopaminergic denervation by detecting loss of striatal dopamine transporters (DaT). OBJECTIVE: We examined DaT binding scores’ (DaTbs) association with motor outcomes in PD and explored its usefulness as a predictor of disease progression. Faster dopaminergic denervation in the basal ganglia was hypothesized to have stronger correlation and predictive value for poor motor outcomes. METHODS: Data was analyzed from the Parkinson's Progression Markers Initiative. DaTbs in the putamen and caudate nucleus were correlated with Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) scores for walking and balance difficulties, gait difficulties, and presence of dyskinesias. A predictive model using baseline speed of drop in DaT binding score was performed for each motor outcome. RESULTS: All motor outcomes had mild, significantly negative correlation with DaTbs in the putamen and caudate nucleus, with similar degree of correlation per region. Speed of drop was predictive of only substantial gait difficulties when evaluated in the putamen but not the caudate. CONCLUSIONS: These findings suggest that analyzing speed of drop in DaTbs, which occurs early in the motor phase of the disease, may be helpful for predicting clinical outcomes in PD. Longer observation of this cohort may provide further data to investigate DaTbs as a prognostic marker in PD. John Wiley & Sons, Inc. 2023-04-05 /pmc/articles/PMC10272916/ /pubmed/37332639 http://dx.doi.org/10.1002/mdc3.13726 Text en © 2023 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Trinh, Ilene
Muralidhar, Angeni
Yang, Justin
Phielipp, Nicolás
Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease
title Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease
title_full Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease
title_fullStr Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease
title_full_unstemmed Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease
title_short Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease
title_sort quantified striatal dopaminergic denervation as predictor for motor outcomes in parkinson's disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272916/
https://www.ncbi.nlm.nih.gov/pubmed/37332639
http://dx.doi.org/10.1002/mdc3.13726
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