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DICER1 platform domain missense variants inhibit miRNA biogenesis and lead to tumor susceptibility

The endoribonuclease DICER1 plays an essential role in the microRNA (miRNA) biogenesis pathway, cleaving precursor miRNA (pre-miRNA) stem-loops to generate mature single-stranded miRNAs. Germline pathogenic variants (GPVs) in DICER1 result in DICER1 tumor predisposition syndrome (DTPS), a mainly chi...

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Detalles Bibliográficos
Autores principales:	Pelletier, Dylan, Chong, Anne-Laure, Wu, Mona, Witkowski, Leora, Albert, Sophie, Sabbaghian, Nelly, Fabian, Marc R, Foulkes, William D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273190/ https://www.ncbi.nlm.nih.gov/pubmed/37333613 http://dx.doi.org/10.1093/narcan/zcad030

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