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Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography

In the last decades, important progress has been achieved in the understanding of the neurotrophic effects of intermittent fasting (IF), calorie restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity and adult neurogenesis (NSPAN) are essential examples of these neurotrophic ef...

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Autor principal: Mayor, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273285/
https://www.ncbi.nlm.nih.gov/pubmed/37334045
http://dx.doi.org/10.3389/fragi.2023.1161814
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author Mayor, Eric
author_facet Mayor, Eric
author_sort Mayor, Eric
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description In the last decades, important progress has been achieved in the understanding of the neurotrophic effects of intermittent fasting (IF), calorie restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity and adult neurogenesis (NSPAN) are essential examples of these neurotrophic effects. The importance in this respect of the metabolic switch from glucose to ketone bodies as cellular fuel has been highlighted. More recently, calorie restriction mimetics (CRMs; resveratrol and other polyphenols in particular) have been investigated thoroughly in relation to NSPAN. In the narrative review sections of this manuscript, recent findings on these essential functions are synthesized and the most important molecules involved are presented. The most researched signaling pathways (PI3K, Akt, mTOR, AMPK, GSK3β, ULK, MAPK, PGC-1α, NF-κB, sirtuins, Notch, Sonic hedgehog and Wnt) and processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart neuroprotection, synaptic plasticity and neurogenesis are then briefly presented. This provides an accessible entry point to the literature. In the annotated bibliography section of this contribution, brief summaries are provided of about 30 literature reviews relating to the neurotrophic effects of interest in relation to IF, CR, CRMs and exercise. Most of the selected reviews address these essential functions from the perspective of healthier aging (sometimes discussing epigenetic factors) and the reduction of the risk for neurodegenerative diseases (Alzheimer’s disease, Huntington’s disease, Parkinson’s disease) and depression or the improvement of cognitive function.
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spelling pubmed-102732852023-06-17 Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography Mayor, Eric Front Aging Aging In the last decades, important progress has been achieved in the understanding of the neurotrophic effects of intermittent fasting (IF), calorie restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity and adult neurogenesis (NSPAN) are essential examples of these neurotrophic effects. The importance in this respect of the metabolic switch from glucose to ketone bodies as cellular fuel has been highlighted. More recently, calorie restriction mimetics (CRMs; resveratrol and other polyphenols in particular) have been investigated thoroughly in relation to NSPAN. In the narrative review sections of this manuscript, recent findings on these essential functions are synthesized and the most important molecules involved are presented. The most researched signaling pathways (PI3K, Akt, mTOR, AMPK, GSK3β, ULK, MAPK, PGC-1α, NF-κB, sirtuins, Notch, Sonic hedgehog and Wnt) and processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart neuroprotection, synaptic plasticity and neurogenesis are then briefly presented. This provides an accessible entry point to the literature. In the annotated bibliography section of this contribution, brief summaries are provided of about 30 literature reviews relating to the neurotrophic effects of interest in relation to IF, CR, CRMs and exercise. Most of the selected reviews address these essential functions from the perspective of healthier aging (sometimes discussing epigenetic factors) and the reduction of the risk for neurodegenerative diseases (Alzheimer’s disease, Huntington’s disease, Parkinson’s disease) and depression or the improvement of cognitive function. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10273285/ /pubmed/37334045 http://dx.doi.org/10.3389/fragi.2023.1161814 Text en Copyright © 2023 Mayor. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Mayor, Eric
Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
title Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
title_full Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
title_fullStr Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
title_full_unstemmed Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
title_short Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
title_sort neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273285/
https://www.ncbi.nlm.nih.gov/pubmed/37334045
http://dx.doi.org/10.3389/fragi.2023.1161814
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