Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses

Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. Here, by mapping 376 immunodominant “public epitopes” at high resolutio...

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Detalles Bibliográficos
Autores principales: Shrock, Ellen L., Timms, Richard T., Kula, Tomasz, Mena, Elijah L., West, Anthony P., Guo, Rui, Lee, I-Hsiu, Cohen, Alexander A., McKay, Lindsay G. A., Bi, Caihong, Keerti, Leng, Yumei, Fujimura, Eric, Horns, Felix, Li, Mamie, Wesemann, Duane R., Griffiths, Anthony, Gewurz, Benjamin E., Bjorkman, Pamela J., Elledge, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273302/
https://www.ncbi.nlm.nih.gov/pubmed/37023193
http://dx.doi.org/10.1126/science.adc9498

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