Treatment decisions and the use of MEK inhibitors for children with neurofibromatosis type 1-related plexiform neurofibromas

Neurofibromatosis type 1 (NF1), the most common tumor predisposition syndrome, occurs when NF1 gene variants result in loss of neurofibromin, a negative regulator of RAS activity. Plexiform neurofibromas (PN) are peripheral nerve sheath tumors that develop in patients with NF1 and are associated wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Armstrong, Amy E., Belzberg, Allan J., Crawford, John R., Hirbe, Angela C., Wang, Zhihong J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273716/
https://www.ncbi.nlm.nih.gov/pubmed/37328781
http://dx.doi.org/10.1186/s12885-023-10996-y

Ejemplares similares

Ejemplares similares