EraSOR: a software tool to eliminate inflation caused by sample overlap in polygenic score analyses

BACKGROUND: Polygenic risk score (PRS) analyses are now routinely applied across biomedical research. However, as PRS studies grow in size, there is an increased risk of sample overlap between the genome-wide association study (GWAS) from which the PRS is derived and the “target sample,” in which PR...

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Detalles Bibliográficos
Autores principales: Choi, Shing Wan, Mak, Timothy Shin Heng, Hoggart, Clive J, O'Reilly, Paul F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273836/
https://www.ncbi.nlm.nih.gov/pubmed/37326441
http://dx.doi.org/10.1093/gigascience/giad043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273836/
https://www.ncbi.nlm.nih.gov/pubmed/37326441
http://dx.doi.org/10.1093/gigascience/giad043

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