Cargando…
Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance
INTRODUCTION: Native T1 mapping values are elevated in acutely injured myocardium. We sought to study whether native T1 values, in the non-infarct related myocardial territories, might differ when supplied by obstructive or nonobstructive coronary arteries. METHODS: Consecutive patients (N = 60, mea...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273906/ https://www.ncbi.nlm.nih.gov/pubmed/36412568 http://dx.doi.org/10.1159/000528143 |
_version_ | 1785059739891138560 |
---|---|
author | Brodov, Yafim Matetzky, Shlomi Konen, Eli Di Segni, Mattia Younis, Anan Massalha, Ayas Berkovitch, Anat Beytelman, Arkadi Chernomordik, Fernando Goitein, Orly |
author_facet | Brodov, Yafim Matetzky, Shlomi Konen, Eli Di Segni, Mattia Younis, Anan Massalha, Ayas Berkovitch, Anat Beytelman, Arkadi Chernomordik, Fernando Goitein, Orly |
author_sort | Brodov, Yafim |
collection | PubMed |
description | INTRODUCTION: Native T1 mapping values are elevated in acutely injured myocardium. We sought to study whether native T1 values, in the non-infarct related myocardial territories, might differ when supplied by obstructive or nonobstructive coronary arteries. METHODS: Consecutive patients (N = 60, mean age 59 years) with the first STEMI following primary percutaneous coronary intervention, underwent cardiac magnetic resonance within 5 ± 2 days. A retrospective review of coronary angiography reports classified coronary arteries as infarct-related coronary artery (IRA) and non-IRA. Obstructive coronary artery disease (CAD) was defined as stenosis ≥50%. Native T1 values were presented using a 16-segment AHA model according to the three main coronary territories: left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA). RESULTS: The cutoff native T1 value for predicting obstructive non-IRA LAD was 1,309 msec with a sensitivity and specificity of 67% and 82%, respectively (AUC 0.76, 95% CI: 0.57–0.95, p = 0.04). The cutoff native T1 value for predicting obstructive non-IRA RCA was 1,302 msec with a sensitivity and specificity of 83% and 55%, respectively (AUC 0.7, 95% CI: 0.52–0.87, p = 0.05). Logistic regression model adjusted for age and infarct size demonstrated that native T1 was an independent predictor for the obstructive non-IRA LAD (OR 4.65; 1.32–26.96, p = 0.05) and RCA (OR 3.70; 1.44–16.35, p = 0.03). CONCLUSION: Elevated native T1 values are independent predictors of obstructive non-IRA in STEMI patients. These results suggest the presence of concomitant remote myocardial impairment in the non-infarct territories with obstructive CAD. |
format | Online Article Text |
id | pubmed-10273906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-102739062023-06-17 Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance Brodov, Yafim Matetzky, Shlomi Konen, Eli Di Segni, Mattia Younis, Anan Massalha, Ayas Berkovitch, Anat Beytelman, Arkadi Chernomordik, Fernando Goitein, Orly Cardiology Cardiovascular Imaging: Research Article INTRODUCTION: Native T1 mapping values are elevated in acutely injured myocardium. We sought to study whether native T1 values, in the non-infarct related myocardial territories, might differ when supplied by obstructive or nonobstructive coronary arteries. METHODS: Consecutive patients (N = 60, mean age 59 years) with the first STEMI following primary percutaneous coronary intervention, underwent cardiac magnetic resonance within 5 ± 2 days. A retrospective review of coronary angiography reports classified coronary arteries as infarct-related coronary artery (IRA) and non-IRA. Obstructive coronary artery disease (CAD) was defined as stenosis ≥50%. Native T1 values were presented using a 16-segment AHA model according to the three main coronary territories: left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA). RESULTS: The cutoff native T1 value for predicting obstructive non-IRA LAD was 1,309 msec with a sensitivity and specificity of 67% and 82%, respectively (AUC 0.76, 95% CI: 0.57–0.95, p = 0.04). The cutoff native T1 value for predicting obstructive non-IRA RCA was 1,302 msec with a sensitivity and specificity of 83% and 55%, respectively (AUC 0.7, 95% CI: 0.52–0.87, p = 0.05). Logistic regression model adjusted for age and infarct size demonstrated that native T1 was an independent predictor for the obstructive non-IRA LAD (OR 4.65; 1.32–26.96, p = 0.05) and RCA (OR 3.70; 1.44–16.35, p = 0.03). CONCLUSION: Elevated native T1 values are independent predictors of obstructive non-IRA in STEMI patients. These results suggest the presence of concomitant remote myocardial impairment in the non-infarct territories with obstructive CAD. S. Karger AG 2023-06 2022-11-22 /pmc/articles/PMC10273906/ /pubmed/36412568 http://dx.doi.org/10.1159/000528143 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by/4.0/This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher. |
spellingShingle | Cardiovascular Imaging: Research Article Brodov, Yafim Matetzky, Shlomi Konen, Eli Di Segni, Mattia Younis, Anan Massalha, Ayas Berkovitch, Anat Beytelman, Arkadi Chernomordik, Fernando Goitein, Orly Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance |
title | Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance |
title_full | Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance |
title_fullStr | Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance |
title_full_unstemmed | Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance |
title_short | Elevated Native T1 Values in the Remote Myocardium Supplied by Obstructive Non-Infarct Related Coronary Arteries in Post-STEMI Cardiac Magnetic Resonance |
title_sort | elevated native t1 values in the remote myocardium supplied by obstructive non-infarct related coronary arteries in post-stemi cardiac magnetic resonance |
topic | Cardiovascular Imaging: Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273906/ https://www.ncbi.nlm.nih.gov/pubmed/36412568 http://dx.doi.org/10.1159/000528143 |
work_keys_str_mv | AT brodovyafim elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT matetzkyshlomi elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT koneneli elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT disegnimattia elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT younisanan elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT massalhaayas elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT berkovitchanat elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT beytelmanarkadi elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT chernomordikfernando elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance AT goiteinorly elevatednativet1valuesintheremotemyocardiumsuppliedbyobstructivenoninfarctrelatedcoronaryarteriesinpoststemicardiacmagneticresonance |