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The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity

BACKGROUND: Obesity, a public health problem, is a state of metainflammation that influences the development of chronic degenerative diseases, particularly in patients with severe obesity. OBJECTIVE: The objective of this study was to evidence immunometabolic differences in patients with different d...

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Autores principales: Rivera-Carranza, Tania, Nájera-Medina, Oralia, Bojalil-Parra, Rafael, Rodríguez-López, Carmen Paulina, Zúñiga-León, Eduardo, León-Téllez Girón, Angélica, Azaola-Espinosa, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274585/
https://www.ncbi.nlm.nih.gov/pubmed/37334132
http://dx.doi.org/10.7717/peerj.15465
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author Rivera-Carranza, Tania
Nájera-Medina, Oralia
Bojalil-Parra, Rafael
Rodríguez-López, Carmen Paulina
Zúñiga-León, Eduardo
León-Téllez Girón, Angélica
Azaola-Espinosa, Alejandro
author_facet Rivera-Carranza, Tania
Nájera-Medina, Oralia
Bojalil-Parra, Rafael
Rodríguez-López, Carmen Paulina
Zúñiga-León, Eduardo
León-Téllez Girón, Angélica
Azaola-Espinosa, Alejandro
author_sort Rivera-Carranza, Tania
collection PubMed
description BACKGROUND: Obesity, a public health problem, is a state of metainflammation that influences the development of chronic degenerative diseases, particularly in patients with severe obesity. OBJECTIVE: The objective of this study was to evidence immunometabolic differences in patients with different degrees of obesity, including severe obesity, by determining correlations between lymphocyte subpopulations and metabolic, body composition, and clinical variables. METHODS: Peripheral blood immune cells (CD4+, CD8+ memory and effector T lymphocytes) were analyzed, and measures of body composition, blood pressure, and biochemical composition (glucose, glycated hemoglobin (HbA1c), insulin, C-reactive protein (CRP), and the lipid profile) were carried out in patients with different degrees of obesity. RESULTS: The patients were classified according to total body fat (TBF) percentage as normal body fat, class 1 and 2 obesity, class 3 obesity, and class 4 obesity. The greater the TBF percentage, the more pronounced the differences in body composition (such as a decrease in the fat-free mass (FFM) that is defined as sarcopenic obesity) and the immunometabolic profile. There was an increase of CD3+ T lymphocytes (mainly CD4+, CD4+CD62-, and CD8+CD45RO+ T lymphocytes) and an increase in the TBF percentage (severity of obesity). CONCLUSIONS: The correlations between lymphocyte subpopulations and metabolic, body composition, and clinical variables demonstrated the existence of a chronic, low-intensity inflammatory process in obesity. Therefore, measuring the immunometabolic profile by means of lymphocyte subpopulations in patients with severe obesity could be useful to determine the severity of the disease and the increased risk of presenting obesity-associated chronic degenerative diseases.
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spelling pubmed-102745852023-06-17 The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity Rivera-Carranza, Tania Nájera-Medina, Oralia Bojalil-Parra, Rafael Rodríguez-López, Carmen Paulina Zúñiga-León, Eduardo León-Téllez Girón, Angélica Azaola-Espinosa, Alejandro PeerJ Nutrition BACKGROUND: Obesity, a public health problem, is a state of metainflammation that influences the development of chronic degenerative diseases, particularly in patients with severe obesity. OBJECTIVE: The objective of this study was to evidence immunometabolic differences in patients with different degrees of obesity, including severe obesity, by determining correlations between lymphocyte subpopulations and metabolic, body composition, and clinical variables. METHODS: Peripheral blood immune cells (CD4+, CD8+ memory and effector T lymphocytes) were analyzed, and measures of body composition, blood pressure, and biochemical composition (glucose, glycated hemoglobin (HbA1c), insulin, C-reactive protein (CRP), and the lipid profile) were carried out in patients with different degrees of obesity. RESULTS: The patients were classified according to total body fat (TBF) percentage as normal body fat, class 1 and 2 obesity, class 3 obesity, and class 4 obesity. The greater the TBF percentage, the more pronounced the differences in body composition (such as a decrease in the fat-free mass (FFM) that is defined as sarcopenic obesity) and the immunometabolic profile. There was an increase of CD3+ T lymphocytes (mainly CD4+, CD4+CD62-, and CD8+CD45RO+ T lymphocytes) and an increase in the TBF percentage (severity of obesity). CONCLUSIONS: The correlations between lymphocyte subpopulations and metabolic, body composition, and clinical variables demonstrated the existence of a chronic, low-intensity inflammatory process in obesity. Therefore, measuring the immunometabolic profile by means of lymphocyte subpopulations in patients with severe obesity could be useful to determine the severity of the disease and the increased risk of presenting obesity-associated chronic degenerative diseases. PeerJ Inc. 2023-06-13 /pmc/articles/PMC10274585/ /pubmed/37334132 http://dx.doi.org/10.7717/peerj.15465 Text en ©2023 Rivera-Carranza et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Nutrition
Rivera-Carranza, Tania
Nájera-Medina, Oralia
Bojalil-Parra, Rafael
Rodríguez-López, Carmen Paulina
Zúñiga-León, Eduardo
León-Téllez Girón, Angélica
Azaola-Espinosa, Alejandro
The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity
title The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity
title_full The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity
title_fullStr The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity
title_full_unstemmed The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity
title_short The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity
title_sort link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274585/
https://www.ncbi.nlm.nih.gov/pubmed/37334132
http://dx.doi.org/10.7717/peerj.15465
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