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Bifurcation in space: Emergence of function modularity in the neocortex

How does functional modularity emerge in a multiregional cortex made with repeats of a canonical local circuit architecture? We investigated this question by focusing on neural coding of working memory, a core cognitive function. Here we report a mechanism dubbed “bifurcation in space”, and show tha...

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Autores principales: Wang, Xiao-Jing, Jiang, Junjie, Pereira-Obilinovic, Ulises
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274618/
https://www.ncbi.nlm.nih.gov/pubmed/37333347
http://dx.doi.org/10.1101/2023.06.04.543639
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author Wang, Xiao-Jing
Jiang, Junjie
Pereira-Obilinovic, Ulises
author_facet Wang, Xiao-Jing
Jiang, Junjie
Pereira-Obilinovic, Ulises
author_sort Wang, Xiao-Jing
collection PubMed
description How does functional modularity emerge in a multiregional cortex made with repeats of a canonical local circuit architecture? We investigated this question by focusing on neural coding of working memory, a core cognitive function. Here we report a mechanism dubbed “bifurcation in space”, and show that its salient signature is spatially localized “critical slowing down” leading to an inverted V-shaped profile of neuronal time constants along the cortical hierarchy during working memory. The phenomenon is confirmed in connectome-based large-scale models of mouse and monkey cortices, offering an experimentally testable prediction to assess whether working memory representation is modular. Many bifurcations in space could explain the emergence of different activity patterns potentially deployed for distinct cognitive functions, This work demonstrates that a distributed mental representation is compatible with functional specificity as a consequence of macroscopic gradients of neurobiological properties across the cortex, suggesting a general principle for understanding brain’s modular organization.
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spelling pubmed-102746182023-06-17 Bifurcation in space: Emergence of function modularity in the neocortex Wang, Xiao-Jing Jiang, Junjie Pereira-Obilinovic, Ulises bioRxiv Article How does functional modularity emerge in a multiregional cortex made with repeats of a canonical local circuit architecture? We investigated this question by focusing on neural coding of working memory, a core cognitive function. Here we report a mechanism dubbed “bifurcation in space”, and show that its salient signature is spatially localized “critical slowing down” leading to an inverted V-shaped profile of neuronal time constants along the cortical hierarchy during working memory. The phenomenon is confirmed in connectome-based large-scale models of mouse and monkey cortices, offering an experimentally testable prediction to assess whether working memory representation is modular. Many bifurcations in space could explain the emergence of different activity patterns potentially deployed for distinct cognitive functions, This work demonstrates that a distributed mental representation is compatible with functional specificity as a consequence of macroscopic gradients of neurobiological properties across the cortex, suggesting a general principle for understanding brain’s modular organization. Cold Spring Harbor Laboratory 2023-06-06 /pmc/articles/PMC10274618/ /pubmed/37333347 http://dx.doi.org/10.1101/2023.06.04.543639 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Wang, Xiao-Jing
Jiang, Junjie
Pereira-Obilinovic, Ulises
Bifurcation in space: Emergence of function modularity in the neocortex
title Bifurcation in space: Emergence of function modularity in the neocortex
title_full Bifurcation in space: Emergence of function modularity in the neocortex
title_fullStr Bifurcation in space: Emergence of function modularity in the neocortex
title_full_unstemmed Bifurcation in space: Emergence of function modularity in the neocortex
title_short Bifurcation in space: Emergence of function modularity in the neocortex
title_sort bifurcation in space: emergence of function modularity in the neocortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274618/
https://www.ncbi.nlm.nih.gov/pubmed/37333347
http://dx.doi.org/10.1101/2023.06.04.543639
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