Single-molecule studies reveal the off-pathway elemental pause state as a target of streptolydigin inhibition of RNA polymerase and its dramatic enhancement by Gre factors

Antibiotic streptolydigin (Stl) inhibits bacterial transcription by blocking the trigger loop folding in the active center of RNA polymerase (RNAP), which is essential for catalysis. We use acoustic force spectroscopy to characterize the dynamics of transcription elongation in ternary elongation com...

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Detalles Bibliográficos
Autores principales: Arseniev, Anatolii, Panfilov, Mikhail, Pobegalov, Georgii, Potyseva, Alina, Pavlinova, Polina, Yakunina, Maria, Lee, Jookyung, Borukhov, Sergei, Severinov, Konstantin, Khodorkovskii, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274647/
https://www.ncbi.nlm.nih.gov/pubmed/37333075
http://dx.doi.org/10.1101/2023.06.05.542125

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