Cargando…

The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice

Mostrar otras versiones (1)

There is now evidence from multiple Phase II clinical trials that psychedelic drugs can exert longlasting anxiolytic, anti-depressant, and anti-drug abuse (nicotine and ethanol) effects in patients. Despite these benefits, the hallucinogenic actions of these drugs at the serotonin 2A receptor (5-HT2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pogorelov, Vladimir M., Rodriguiz, Ramona M., Roth, Bryan L., Wetsel, William C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274653/ https://www.ncbi.nlm.nih.gov/pubmed/37333376 http://dx.doi.org/10.1101/2023.06.01.543310

Ejemplares similares

The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice
por: Pogorelov, Vladimir M., et al.
Publicado: (2023)

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
por: Rodriguiz, Ramona M., et al.
Publicado: (2021)

Lisuride toxicity in a pediatric patient
por: Alahmadi, Tahani A., et al.
Publicado: (2013)

LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor
por: Halberstadt, Adam L., et al.
Publicado: (2009)

PM435. Targeting Functional Selectivity of the Dopamine D2 Receptor for Treatment of Schizophrenia-like Behaviors
por: Wetsel, William, et al.
Publicado: (2016)

Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists
por: Pogorelov, Vladimir M., et al.
Publicado: (2023)

Selective serotonin 5-HT(1A) receptor biased agonists elicitdistinct brain activation patterns: a pharmacoMRI study
por: Becker, G., et al.
Publicado: (2016)

Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model
por: Velagapudi, Ravikanth, et al.
Publicado: (2019)

Rearing behaviour in the mouse behavioural pattern monitor distinguishes the effects of psychedelics from those of lisuride and TBG
por: Chen, Yahong, et al.
Publicado: (2023)

Role of prucalopride, a serotonin (5-HT(4)) receptor agonist, for the treatment of chronic constipation
por: Wong, Banny S, et al.
Publicado: (2010)

Crystal structure of the human 5-HT(1B) serotonin receptor bound to an inverse agonist
por: Yin, Wanchao, et al.
Publicado: (2018)

Molecular insights into the regulation of constitutive activity by RNA editing of 5HT(2C) serotonin receptors
por: Gumpper, Ryan H., et al.
Publicado: (2022)

Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease
por: Nagy, Eniko, et al.
Publicado: (2016)

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
por: Gorinski, Nataliya, et al.
Publicado: (2019)

Effects of Tiliroside and Lisuride Co-Treatment on the PI3K/Akt Signal Pathway: Modulating Neuroinflammation and Apoptosis in Parkinson’s Disease
por: Alkholifi, Faisal K., et al.
Publicado: (2023)

Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants
por: Pogorelov, Vladimir M, et al.
Publicado: (2019)

Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression
por: Liu, Mei-Yan, et al.
Publicado: (2015)

Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice
por: McGaughey, Kara D., et al.
Publicado: (2019)

Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
por: Neumann, Joachim, et al.
Publicado: (2023)

Neurotrophic Factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone
por: Cheng, Yong, et al.
Publicado: (2014)

Translating the promise of 5HT(4) receptor agonists for the treatment of depression
por: Murphy, Susannah E, et al.
Publicado: (2021)

GPER Agonist G1 Prevents Wnt-Induced JUN Upregulation in HT29 Colorectal Cancer Cells
por: Abancens, Maria, et al.
Publicado: (2022)

Altered 5-HT(2C )receptor agonist-induced responses and 5-HT(2C )receptor RNA editing in the amygdala of serotonin transporter knockout mice
por: Moya, Pablo R, et al.
Publicado: (2011)

Antidepressant-Like Activity of YL-0919: A Novel Combined Selective Serotonin Reuptake Inhibitor and 5-HT(1A) Receptor Agonist
por: Chen, Hong-xia, et al.
Publicado: (2013)

N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT(2) Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues
por: Nichols, David E., et al.
Publicado: (2014)

MeCP2 in the Nucleus Accumbens Contributes to Neural and Behavioral Responses to Psychostimulants
por: Deng, Jie V., et al.
Publicado: (2010)

Azologization of serotonin 5-HT(3) receptor antagonists
por: Rustler, Karin, et al.
Publicado: (2019)

Gα Protein Signaling Bias at Serotonin 1A Receptor
por: Alabdali, Rana, et al.
Publicado: (2023)

Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT(2A) Receptor Agonists
por: Poulie, Christian B. M., et al.
Publicado: (2022)

Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT(3A) and 5-HT(6) receptor subtypes
por: Vitalis, Tania, et al.
Publicado: (2013)

Biophysical validation of serotonin 5-HT(2A) and 5-HT(2C) receptor interaction
por: Felsing, Daniel E., et al.
Publicado: (2018)

Cryo-EM structure of the serotonin 5-HT(1B) receptor coupled to heterotrimeric G(o)
por: García-Nafría, Javier, et al.
Publicado: (2018)

Structural insights into the ligand binding and G(i) coupling of serotonin receptor 5-HT(5A)
por: Tan, Yangxia, et al.
Publicado: (2022)

Serotonin 5-HT(7) receptor slows down the G(s) protein: a single molecule perspective
por: Petelák, Aleš, et al.
Publicado: (2023)

Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia
por: Jiang, Zhao-Cai, et al.
Publicado: (2014)

Serotonin 5-HT(4) Receptor Agonists Improve Facilitation of Contextual Fear Extinction in an MPTP-Induced Mouse Model of Parkinson’s Disease
por: Ishii, Toshiaki, et al.
Publicado: (2019)

The selective 5-HT(1A) receptor agonist, NLX-112, exerts anti-dyskinetic and anti-parkinsonian-like effects in MPTP-treated marmosets
por: Fisher, Ria, et al.
Publicado: (2020)

GIT1 regulates synaptic structural plasticity underlying learning
por: Martyn, Amanda C., et al.
Publicado: (2018)

The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders
por: Miller-Rhodes, Patrick, et al.
Publicado: (2019)

Marmoset Serotonin 5-HT(1A) Receptor Mapping with a Biased Agonist PET Probe (18)F-F13714: Comparison with an Antagonist Tracer (18)F-MPPF in Awake and Anesthetized States
por: Yokoyama, Chihiro, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ov68pnv9iee96t99b8s9ghtnsj