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Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers

Chronic infection of hepatitis B virus (HBV) is caused by the persistence of closed circular DNA (cccDNA) in the nucleus of infected hepatocytes. Despite available therapeutic anti-HBV agents, eliminating the cccDNA remains challenging. The quantifying and understanding dynamics of cccDNA are essent...

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Detalles Bibliográficos
Autores principales:	Kitagawa, Kosaku, Kim, Kwang Su, Iwamoto, Masashi, Hayashi, Sanae, Park, Hyeongki, Nishiyama, Takara, Nakamura, Naotoshi, Fujita, Yasuhisa, Nakaoka, Shinji, Aihara, Kazuyuki, Perelson, Alan S., Allweiss, Lena, Dandri, Maura, Watashi, Koichi, Tanaka, Yasuhito, Iwami, Shingo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274663/ https://www.ncbi.nlm.nih.gov/pubmed/37333409 http://dx.doi.org/10.1101/2023.06.06.543822

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