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Catalytic activity of the Bin3/MEPCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster
Methylphosphate Capping Enzyme (MEPCE) monomethylates the gamma phosphate at the 5’ end of the 7SK noncoding RNA, a modification thought to protect 7SK from degradation. 7SK serves as a scaffold for assembly of a snRNP complex that inhibits transcription by sequestering the positive elongation facto...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274667/ https://www.ncbi.nlm.nih.gov/pubmed/37333392 http://dx.doi.org/10.1101/2023.06.01.543302 |