Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell states

Cellular perturbations underlying Alzheimer’s disease are primarily studied in human postmortem samples and model organisms. Here we generated a single-nucleus atlas from a rare cohort of cortical biopsies from living individuals with varying degrees of Alzheimer’s disease pathology. We next perform...

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Detalles Bibliográficos
Autores principales: Gazestani, Vahid, Kamath, Tushar, Nadaf, Naeem M., Burris, SJ, Rooney, Brendan, Junkkari, Antti, Vanderburg, Charles, Rauramaa, Tuomas, Therrien, Martine, Tegtmeyer, Matthew, Herukka, Sanna-Kaisa, Abdulraouf, Abdulraouf, Marsh, Samuel, Malm, Tarja, Hiltunen, Mikko, Nehme, Ralda, Stevens, Beth, Leinonen, Ville, Macosko, Evan Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274680/
https://www.ncbi.nlm.nih.gov/pubmed/37333365
http://dx.doi.org/10.1101/2023.06.03.543569

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