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Recording morphogen signals reveals origins of gastruloid symmetry breaking

When cultured in three dimensional spheroids, mammalian stem cells can reproducibly self-organize a single anterior-posterior axis and sequentially differentiate into structures resembling the primitive streak and tailbud. Whereas the embryo’s body axes are instructed by spatially patterned extra-em...

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Detalles Bibliográficos
Autores principales: McNamara, Harold M., Solley, Sabrina C., Adamson, Britt, Chan, Michelle M., Toettcher, Jared E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274695/
https://www.ncbi.nlm.nih.gov/pubmed/37333235
http://dx.doi.org/10.1101/2023.06.02.543474