Strain-dependent effects on neurobehavioral and seizure phenotypes in Scn2a(K1422E) mice

Pathogenic variants in SCN2A are associated with a range of neurodevelopmental disorders (NDD). Despite being largely monogenic, SCN2A-related NDD show considerable phenotypic variation and complex genotype-phenotype correlations. Genetic modifiers can contribute to variability in disease phenotypes...

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Detalles Bibliográficos
Autores principales: Echevarria-Cooper, Dennis M., Hawkins, Nicole A., Kearney, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274703/
https://www.ncbi.nlm.nih.gov/pubmed/37333275
http://dx.doi.org/10.1101/2023.06.06.543929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274703/
https://www.ncbi.nlm.nih.gov/pubmed/37333275
http://dx.doi.org/10.1101/2023.06.06.543929

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