Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction

Type I interferons (IFNs) increase the excitability of dorsal root ganglion (DRG) neurons via activation of MNK-eIF4E translation signaling to promote pain sensitization in mice. Activation of STING signaling is a key component of type I IFN induction. Manipulation of STING signaling is an active ar...

Descripción completa

Detalles Bibliográficos
Autores principales: Franco-Enzástiga, Úrzula, Natarajan, Keerthana, David, Eric T., Patel, Krish J., Ravirala, Abhira, Price, Theodore J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274710/
https://www.ncbi.nlm.nih.gov/pubmed/37333411
http://dx.doi.org/10.1101/2023.06.03.543579

Ejemplares similares

Ejemplares similares