DREADD-mediated amygdala activation is sufficient to induce anxiety-like responses in young nonhuman primates

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Anxiety disorders are among the most prevalent psychiatric disorders, with symptoms often beginning early in life. To model the pathophysiology of human pathological anxiety, we utilized Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in a nonhuman primate model of anxious tempe...

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Detalles Bibliográficos
Autores principales: Mueller, Sascha A.L., Oler, Jonathan A., Roseboom, Patrick H., Aggarwal, Nakul, Kenwood, Margaux M., Riedel, Marissa K., Elam, Victoria R., Olsen, Miles E., DiFilippo, Alexandra H., Christian, Bradley T., Hu, Xing, Galvan, Adriana, Boehm, Matthew A., Michaelides, Michael, Kalin, Ned H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274719/
https://www.ncbi.nlm.nih.gov/pubmed/37333300
http://dx.doi.org/10.1101/2023.06.06.543911
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