Disruption of Prostaglandin F(2α) Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is a chronic parenchymal lung disease characterized by repetitive alveolar cell injury, myofibroblast proliferation, and excessive extracellular matrix deposition for which unmet need persists for effective therapeutics. The bioactive eicosanoid, prostaglandin F2α...

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Detalles Bibliográficos
Autores principales: Rodriguez, Luis R., Tang, Soon Yew, Barboza, Willy Roque, Murthy, Aditi, Tomer, Yaniv, Cai, Tian-Quan, Iyer, Swati, Chavez, Katrina, Das, Ujjalkumar Subhash, Ghosh, Soumita, Dimopoulos, Thalia, Babu, Apoorva, Connelly, Caitlin, FitzGerald, Garret A., Beers, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274762/
https://www.ncbi.nlm.nih.gov/pubmed/37333249
http://dx.doi.org/10.1101/2023.06.07.543956

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