The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

Membrane transporters play a fundamental role in the tissue distribution of endogenous compounds and xenobiotics and are major determinants of efficacy and side effects profiles. Polymorphisms within these drug transporters result in inter-individual variation in drug response, with some patients no...

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Detalles Bibliográficos
Autores principales: Yee, Sook Wah, Macdonald, Christian, Mitrovic, Darko, Zhou, Xujia, Koleske, Megan L., Yang, Jia, Silva, Dina Buitrago, Grimes, Patrick Rockefeller, Trinidad, Donovan, More, Swati S., Kachuri, Linda, Witte, John S., Delemotte, Lucie, Giacomini, Kathleen M., Coyote-Maestas, Willow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274788/
https://www.ncbi.nlm.nih.gov/pubmed/37333090
http://dx.doi.org/10.1101/2023.06.06.543963

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