An evolutionarily conserved strategy for ribosome binding and inhibition by β-coronavirus non-structural protein 1

An important pathogenicity factor of SARS-CoV-2 and related coronaviruses is Nsp1, which suppresses host gene expression and stunts antiviral signaling. SARS-CoV-2 Nsp1 binds the ribosome to inhibit translation through mRNA displacement and induces degradation of host mRNAs through an unknown mechan...

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Detalles Bibliográficos
Autores principales: Maurina, Stephanie F., O’Sullivan, John P., Sharma, Geetika, Pineda Rodriguez, Daniel C., MacFadden, Andrea, Cendali, Francesca, Henen, Morkos A., Kieft, Jeffrey S., Glasgow, Anum, Steckelberg, Anna-Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274807/
https://www.ncbi.nlm.nih.gov/pubmed/37333070
http://dx.doi.org/10.1101/2023.06.07.544141

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