Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory

A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element binding protein 3 (CPEB3) gene is thought to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. We tested the activity of the murine sequence and found tha...

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Detalles Bibliográficos
Autores principales: Chen, Claire C., Han, Joseph, Chinn, Carlene A., Rounds, Jacob S., Li, Xiang, Nikan, Mehran, Myszka, Marie, Tong, Liqi, Passalacqua, Luiz F. M., Bredy, Timothy W., Wood, Marcelo A., Lupták, Andrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274809/
https://www.ncbi.nlm.nih.gov/pubmed/37333407
http://dx.doi.org/10.1101/2023.06.07.543953

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