Cargando…

Innate immune responses yield tissue-specific bottlenecks that scale with pathogen dose

Mostrar otras versiones (1)

To cause infection, pathogens must overcome bottlenecks imposed by the host immune system. These bottlenecks restrict the inoculum and largely determine whether pathogen exposure results in disease. Infection bottlenecks therefore quantify the effectiveness of immune barriers. Here, using a model of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hullahalli, Karthik, Dailey, Katherine G., Waldor, Matthew K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274871/ https://www.ncbi.nlm.nih.gov/pubmed/37333208 http://dx.doi.org/10.1101/2023.06.09.543079

Ejemplares similares

Innate immune responses yield tissue-specific bottlenecks that scale with pathogen dose
por: Hullahalli, Karthik, et al.
Publicado: (2023)

Refined Quantification of Infection Bottlenecks and Pathogen Dissemination with STAMPR
por: Hullahalli, Karthik, et al.
Publicado: (2021)

Quantitative dose-response analysis untangles host bottlenecks to enteric infection
por: Campbell, Ian W., et al.
Publicado: (2023)

Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection
por: Hullahalli, Karthik, et al.
Publicado: (2021)

Genetic and immune determinants of E. coli liver abscess formation
por: Hullahalli, Karthik, et al.
Publicado: (2023)

Analysis of Bottlenecks in Experimental Models of Infection
por: Abel, Sören, et al.
Publicado: (2015)

Identification and Validation of Ifit1 as an Important Innate Immune Bottleneck
por: McDermott, Jason E., et al.
Publicado: (2012)

Undecaprenyl phosphate translocases confer conditional microbial fitness
por: Sit, Brandon, et al.
Publicado: (2022)

Phagocytosis, Innate Immunity, and Host–Pathogen Specificity
por: Henneke, Phillip, et al.
Publicado: (2004)

A Bottleneck Model of Set-Specific Capture
por: Moore, Katherine Sledge, et al.
Publicado: (2014)

Nontoxigenic Vibrio cholerae Challenge Strains for Evaluating Vaccine Efficacy and Inferring Mechanisms of Protection
por: Fakoya, Bolutife, et al.
Publicado: (2022)

Overcoming Data Bottlenecks in Genomic Pathogen Surveillance
por: Afolayan, Ayorinde O, et al.
Publicado: (2021)

Big bottlenecks in cardiovascular tissue engineering
por: Huang, Ngan F., et al.
Publicado: (2018)

Spatiotemporal dynamics of traffic bottlenecks yields an early signal of heavy congestions
por: Duan, Jinxiao, et al.
Publicado: (2023)

Scaling malaria interventions: bottlenecks to malaria elimination
por: Mao, Wenhui, et al.
Publicado: (2023)

Variation at Innate Immunity Toll-Like Receptor Genes in a Bottlenecked Population of a New Zealand Robin
por: Grueber, Catherine E., et al.
Publicado: (2012)

Specific Pathogen Recognition by Multiple Innate Immune Sensors in an Invertebrate
por: Tetreau, Guillaume, et al.
Publicado: (2017)

Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity
por: Häder, Antje, et al.
Publicado: (2023)

Cryopreservation of tissues and organs: present, bottlenecks, and future
por: Chen, Jiangming, et al.
Publicado: (2023)

Pathogenic selection promotes adaptive immune variations against serious bottlenecks in early invasions of bullfrogs
por: Zhang, Jiaqi, et al.
Publicado: (2023)

SARS-CoV-2 Bottlenecks and Tissue-Specific Adaptation in the Central Nervous System
por: Richner, Justin, et al.
Publicado: (2023)

Pathogenicity and innate immune responses induced by fowl adenovirus serotype 8b in specific pathogen-free chicken
por: Zhang, Xiaona, et al.
Publicado: (2023)

Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
por: Xiao, Yinghong, et al.
Publicado: (2017)

On the Difference between the Information Bottleneck and the Deep Information Bottleneck
por: Wieczorek, Aleksander, et al.
Publicado: (2020)

Pathogenicity and tissue tropism of infectious bronchitis virus is associated with elevated apoptosis and innate immune responses
por: Chhabra, Rajesh, et al.
Publicado: (2016)

Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish
por: van der Vaart, Michiel, et al.
Publicado: (2012)

Innate immune responses induced by the saponin adjuvant Matrix-M in specific pathogen free pigs
por: Ahlberg, Viktor, et al.
Publicado: (2017)

Out of the bottleneck
por: Charpak, Georges
Publicado: (2004)

The Business Bottleneck
por: Cote, Michael
Publicado: (2020)

Immune Evasion Strategies of Ranaviruses and Innate Immune Responses to These Emerging Pathogens
por: Grayfer, Leon, et al.
Publicado: (2012)

Pathogen population bottlenecks and adaptive landscapes: overcoming the barriers to disease emergence
por: Geoghegan, Jemma L., et al.
Publicado: (2016)

Low-dose exposure to PBDE disrupts genomic integrity and innate immunity in mammary tissue
por: Lamkin, Donald M., et al.
Publicado: (2022)

Self-harm to preferentially harm the pathogens within: non-specific stressors in innate immunity
por: LeGrand, Edmund K., et al.
Publicado: (2016)

Androgens Upregulate Pathogen-Induced Placental Innate Immune Response
por: Vancolen, Seline, et al.
Publicado: (2022)

Innate immune responses against the fungal pathogen Candida auris
por: Wang, Yuanyuan, et al.
Publicado: (2022)

Pathogenicity, colonization, and innate immune response to Pasteurella multocida in rabbits
por: Yang, Wenhao, et al.
Publicado: (2022)

Autophagy in Innate Recognition of Pathogens and Adaptive Immunity
por: Oh, Ji Eun, et al.
Publicado: (2012)

Innate Immunity and the Pathogenicity of Inhaled Microbial Particles
por: Wolff, C. Henrik J.
Publicado: (2011)

Pathogen recognition by innate immunity and its signaling
por: Akira, Shizuo
Publicado: (2009)

Exploiting CRISPR-Cas to manipulate Enterococcus faecalis populations
por: Hullahalli, Karthik, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8qpcigbhal9ap0diglmqln4pkn