RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

We previously demonstrated that RNA helicase DDX3X (DDX3) can be a therapeutic target in Ewing sarcoma (EWS), but its role in EWS biology remains unclear. The present work demonstrates that DDX3 plays a unique role in DNA damage repair (DDR). We show that DDX3 interacts with several proteins involve...

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Detalles Bibliográficos
Autores principales: Randolph, Matthew E., Afifi, Marwa, Gorthi, Aparna, Weil, Rachel, Wilky, Breelyn A., Weinreb, Joshua, Ciero, Paul, ter Hoeve, Natalie, van Diest, Paul J., Raman, Venu, Bishop, Alexander J. R., Loeb, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274875/
https://www.ncbi.nlm.nih.gov/pubmed/37333164
http://dx.doi.org/10.1101/2023.06.10.544474

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