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TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

Unbiased proteomics has been employed to interrogate central nervous system (CNS) tissues (brain, spinal cord) and fluid matrices (CSF, plasma) from amyotrophic lateral sclerosis (ALS) patients; yet, a limitation of conventional bulk tissue studies is that motor neuron (MN) proteome signals may be c...

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Detalles Bibliográficos
Autores principales:	Guise, Amanda J., Misal, Santosh A., Carson, Richard, Boekweg, Hannah, Watt, Daisha Van Der, Truong, Thy, Liang, Yiran, Chu, Jen-Hwa, Welsh, Nora C., Gagnon, Jake, Payne, Samuel H., Plowey, Edward D., Kelly, Ryan T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274884/ https://www.ncbi.nlm.nih.gov/pubmed/37333094 http://dx.doi.org/10.1101/2023.06.08.544233

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