Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness

Brain metabolism perturbation can contribute to traits and diseases. We conducted the first large-scale CSF and brain genome-wide association studies, which identified 219 independent associations (59.8% novel) for 144 CSF metabolites and 36 independent associations (55.6% novel) for 34 brain metabo...

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Detalles Bibliográficos
Autores principales: Wang, Ciyang, Western, Dan, Yang, Chengran, Ali, Muhammad, Wang, Lihua, Gorijala, Priyanka, Timsina, Jigyasha, Ruiz, Agustín, Pastor, Pau, Fernandez, Maria, Panyard, Daniel, Engelman, Corinne, Deming, Yuetiva, Boada, Merce, Cano, Amanda, García-González, Pablo, Graff-Radford, Neill, Mori, Hiroshi, Lee, Jae-Hong, Perrin, Richard, Sung, Yun Ju, Cruchaga, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274943/
https://www.ncbi.nlm.nih.gov/pubmed/37333177
http://dx.doi.org/10.21203/rs.3.rs-2923409/v1

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