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Ebola Virus NP Binding to Host Protein Phosphatase-1 Regulates Capsid Formation
The Ebola virus (EBOV) transcriptional regulation involves host protein phosphatases PP1 and PP2A, which dephosphorylate the transcriptional cofactor of EBOV polymerase VP30. The 1E7–03 compound, which targets PP1, induces VP30 phosphorylation and inhibits EBOV infection. This study aimed to investi...
Autores principales: | Ahmad, Asrar, Tigabu, Bersabeh, Ivanov, Andrey, Jerebtsova, Marina, Ammosova, Tatiana, Ramanathan, Palaniappan, Kumari, Namita, Brantner, Christine A., Pietzsch, Colette A., Abdullah, Ghadeer, Popratiloff, Anastas, Widen, Steve, Bukreyev, Alexander, Nekhai, Sergei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274954/ https://www.ncbi.nlm.nih.gov/pubmed/37333330 http://dx.doi.org/10.21203/rs.3.rs-2963943/v1 |
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