HIV-1 5’-Leader Mutations in Plasma Viruses Before and After the Development of Reverse Transcriptase Inhibitor-Resistance Mutations

BACKGROUND: HIV-1 RT initiation depends on interaction between viral 5’-leader RNA, RT, and host tRNA3(Lys). We therefore sought to identify co-evolutionary changes between the 5’-leader and RT in viruses developing RT-inhibitor resistance mutations. METHODS: We sequenced 5’-leader positions 37–356...

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Detalles Bibliográficos
Autores principales: Nouhin, Janin, Tzou, Philip L., Rhee, Soo-Yon, Sahoo, Malaya K., Pinsky, Benjamin A., Krupkin, Miri, Puglisi, Joseph D., Puglisi, Elisabetta V., Shafer, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274971/
https://www.ncbi.nlm.nih.gov/pubmed/37333388
http://dx.doi.org/10.1101/2023.06.04.23290942

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