ApoER2-Dab1 disruption as the origin of pTau-related neurodegeneration in sporadic Alzheimer’s disease

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BACKGROUND: Sporadic Alzheimer’s disease (sAD) is not a global brain disease. Specific regions, layers and neurons degenerate early while others remain untouched even in advanced disease. The prevailing model used to explain this selective neurodegeneration—prion-like Tau spread—has key limitations...

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Detalles Bibliográficos
Autores principales: Ramsden, Christopher E., Zamora, Daisy, Horowitz, Mark S., Jahanipour, Jahandar, Keyes, Gregory S., Li, Xiufeng, Murray, Helen C., Curtis, Maurice A., Faull, Richard M., Sedlock, Andrea, Maric, Dragan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274982/
https://www.ncbi.nlm.nih.gov/pubmed/37333406
http://dx.doi.org/10.1101/2023.05.19.23290250
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