Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease

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Alzheimer’s disease (AD) heritability is enriched in glial genes, but how and when cell-type-specific genetic risk contributes to AD remains unclear. Here, we derive cell-type-specific AD polygenic risk scores (ADPRS) from two extensively characterized datasets. In an autopsy dataset spanning all st...

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Detalles Bibliográficos
Autores principales: Yang, Hyun-Sik, Teng, Ling, Kang, Daniel, Menon, Vilas, Ge, Tian, Finucane, Hilary K., Schultz, Aaron P., Properzi, Michael, Klein, Hans-Ulrich, Chibnik, Lori B., Schneider, Julie A., Bennett, David A., Hohman, Timothy J., Mayeux, Richard P., Johnson, Keith A., De Jager, Philip L., Sperling, Reisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274993/
https://www.ncbi.nlm.nih.gov/pubmed/37333223
http://dx.doi.org/10.1101/2023.06.01.23290850
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