Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy

Enhanced DNA repair is an important mechanism of inherent and acquired resistance to DNA targeted therapies, including poly ADP ribose polymerase inhibition. Spleen associated tyrosine kinase (Syk) is a non-receptor tyrosine kinase known to regulate immune cell function, cell adhesion, and vascular...

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Detalles Bibliográficos
Autores principales: Zhou, Qin, Tu, Xinyi, Hou, Xiaonan, Yu, Jia, Zhao, Fei, Huang, Jinzhou, Kloeber, Jake, Olson, Anna, Gao, Ming, Luo, Kuntian, Zhu, Shouhai, Wu, Zheming, Zhang, Yong, Sun, Chenyu, Zeng, Xiangyu, Schoolmeester, Kenneth, Weroha, John, Wang, Liewei, Mutter, Robert, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275042/
https://www.ncbi.nlm.nih.gov/pubmed/37333340
http://dx.doi.org/10.21203/rs.3.rs-2922520/v1

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