MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection

MV140 is a mucosal vaccine of inactivated whole bacteria (E. coli, K. pneumoniae, E. faecalis, P. vulgaris) with clinical efficacy against recurrent urinary tract infections (UTIs). Here, MV140 was evaluated in a murine model of acute uropathogenic E. coli (UPEC)-induced UTI using the UTI89 strain....

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Autores principales: Saz-Leal, Paula, Ligon, Marianne M., Diez-Rivero, Carmen M., García-Ayuso, Diego, Mohanty, Soumitra, Conejero, Laura, Brauner, Annelie, Subiza, José L., Mysorekar, Indira U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275044/
https://www.ncbi.nlm.nih.gov/pubmed/37333312
http://dx.doi.org/10.21203/rs.3.rs-2992611/v1
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author Saz-Leal, Paula
Ligon, Marianne M.
Diez-Rivero, Carmen M.
García-Ayuso, Diego
Mohanty, Soumitra
Conejero, Laura
Brauner, Annelie
Subiza, José L.
Mysorekar, Indira U.
author_facet Saz-Leal, Paula
Ligon, Marianne M.
Diez-Rivero, Carmen M.
García-Ayuso, Diego
Mohanty, Soumitra
Conejero, Laura
Brauner, Annelie
Subiza, José L.
Mysorekar, Indira U.
author_sort Saz-Leal, Paula
collection PubMed
description MV140 is a mucosal vaccine of inactivated whole bacteria (E. coli, K. pneumoniae, E. faecalis, P. vulgaris) with clinical efficacy against recurrent urinary tract infections (UTIs). Here, MV140 was evaluated in a murine model of acute uropathogenic E. coli (UPEC)-induced UTI using the UTI89 strain. MV140 vaccination resulted in UPEC clearance, concomitant with increased influx of myeloid cells in urine, CD4+ T cells in the bladder, and a systemic adaptive immune response to both MV140-containing E. coli and UTI89.
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spelling pubmed-102750442023-06-17 MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection Saz-Leal, Paula Ligon, Marianne M. Diez-Rivero, Carmen M. García-Ayuso, Diego Mohanty, Soumitra Conejero, Laura Brauner, Annelie Subiza, José L. Mysorekar, Indira U. Res Sq Article MV140 is a mucosal vaccine of inactivated whole bacteria (E. coli, K. pneumoniae, E. faecalis, P. vulgaris) with clinical efficacy against recurrent urinary tract infections (UTIs). Here, MV140 was evaluated in a murine model of acute uropathogenic E. coli (UPEC)-induced UTI using the UTI89 strain. MV140 vaccination resulted in UPEC clearance, concomitant with increased influx of myeloid cells in urine, CD4+ T cells in the bladder, and a systemic adaptive immune response to both MV140-containing E. coli and UTI89. American Journal Experts 2023-06-07 /pmc/articles/PMC10275044/ /pubmed/37333312 http://dx.doi.org/10.21203/rs.3.rs-2992611/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. https://creativecommons.org/licenses/by/4.0/License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Saz-Leal, Paula
Ligon, Marianne M.
Diez-Rivero, Carmen M.
García-Ayuso, Diego
Mohanty, Soumitra
Conejero, Laura
Brauner, Annelie
Subiza, José L.
Mysorekar, Indira U.
MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection
title MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection
title_full MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection
title_fullStr MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection
title_full_unstemmed MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection
title_short MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection
title_sort mv140 mucosal bacterial vaccine improves uropathogenic e. coli clearance in an experimental model of urinary tract infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275044/
https://www.ncbi.nlm.nih.gov/pubmed/37333312
http://dx.doi.org/10.21203/rs.3.rs-2992611/v1
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