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Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using the OLIG2 inhibitor CT-179

Recurrence is the primary life-threatening complication for medulloblastoma (MB). In Sonic Hedgehog (SHH)-subgroup MB, OLIG2-expressing tumor stem cells drive recurrence. We investigated the anti-tumor potential of the small-molecule OLIG2 inhibitor CT-179, using SHH-MB patient-derived organoids, pa...

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Detalles Bibliográficos
Autores principales:	Li, Yuchen, Lim, Chaemin, Dismuke, Taylor, Malawsky, Daniel S., Oasa, Sho, Bruce, Zara C., Offenhäuser, Carolin, Baumgartner, Ulrich, D’Souza, Rochelle C. J., Edwards, Stacey L., French, Juliet D., Ock, Lucy S.H., Nair, Sneha, Sivakumaran, Haran, Harris, Lachlan, Tikunov, Andrey P., Hwang, Duhyeong, Del Mar Alicea Pauneto, Coral, Maybury, Mellissa, Hassall, Timothy, Wainwright, Brandon, Kesari, Santosh, Stein, Gregory, Piper, Michael, Johns, Terrance G., Sokolsky-Papkov, Marina, Terenius, Lars, Vukojević, Vladana, Gershon, Timothy R., Day, Bryan W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275055/ https://www.ncbi.nlm.nih.gov/pubmed/37333134 http://dx.doi.org/10.21203/rs.3.rs-2949436/v1

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